Device built-in

Uncle High-Throughput Multi-Parameter Protein Stability Analyzer - Product Introduction

The Uncle High-Throughput Multi-Parameter Protein Stability Analyzer is a revolutionary protein analysis platform that integrates dynamic light scattering (DLS), static light scattering (SLS), and fluorescence detection technologies. It enables simultaneous measurement of protein size distribution, aggregation state, thermal stability, and conformational changes with ultra-low sample volumes (as little as 4μL). This instrument is widely used in biopharmaceutical development, vaccine research, gene therapy, and protein engineering, significantly accelerating R&D workflows.

Key Features

1. Multi-Parameter Analysis

   • Single-run measurements: Tm (melting temperature), particle size (DLS), aggregation propensity (SLS), and intrinsic/extrinsic fluorescence, providing comprehensive protein stability profiles.
   • Label-free detection preserves native protein properties without dyes or modifications.

2. High Throughput & Automation

   • 96-well plate compatibility enables screening of hundreds of samples per hour.
   • Automated temperature control (4–95°C) with customizable ramp rates (0.1–2°C/min) to simulate environmental stresses.

3. High Sensitivity & Precision

   • Detection limit as low as 0.1 mg/mL, ideal for precious samples (e.g., antibodies, viral vectors).
   • Patented optics minimize background noise, delivering CV <5% data reproducibility.

4. AI-Powered Data Analytics

   • Built-in AI-assisted software automatically fits thermal denaturation curves, predicts aggregation risks, and generates exportable reports (PDF/Excel).
   • 21 CFR Part 11 compliant with audit trails and e-signatures for GMP/GLP compliance.

Applications

• Biopharmaceuticals: Antibody thermal optimization, fusion protein conformational analysis.
• Vaccines: Stability assessment of virus-like particles (VLPs).
• Gene Therapy: AAV vector empty/full capsid ratio analysis.
• Basic Research: Protein-ligand interaction studies.

Technical Advantages

Uncle redefines protein characterization by combining multi-parameter detection, minimal sample consumption, and high throughput—resolving limitations of traditional methods (e.g., DSF, SEC-MALS) that require multiple instruments and large sample volumes. It accelerates transition from candidate molecules to preclinical studies.

Fields of Use: Pharma companies, CROs/CDMOs, academic labs, QC facilities.
Optional Upgrades: Autosampler, multi-fluorescence channels, compliance validation services.

(Note: "Uncle" is a brand name derived from "Universal Characterization Lab Equipment.")