Device built-in

AB SCIEX TripleTOF 6600 LC-MS/MS System Introduction

Product Overview
The AB SCIEX TripleTOF 6600 is a high-resolution accurate mass (HRAM) liquid chromatography-tandem mass spectrometry (LC-MS/MS) system developed by SCIEX (a Danaher Corporation company). Integrating quadrupole-time-of-flight (Q-TOF) dual mass analyzers with SelexION ion mobility technology, it was awarded "2016 Best Mass Spectrometry Product" by The Analytical Scientist. The system's revolutionary SWATH Acquisition technology enables comprehensive biomarker discovery and precise quantitative analysis.

Core Technological Advantages

1. Ultra-High Resolution Detection

   • Mass resolution >40,000 FWHM (at m/z 956) with <2 ppm mass accuracy
   • TOF V-shaped ion mirror design achieves 100 spectra/second acquisition speed

2. Triple Analysis Capability

   • Simultaneous MS (precursor ion scan), MS/MS (product ion scan), and SWATH (data-independent acquisition)
   • SelexION ion mobility separates isomers with 1 spatial structure differences

3. Intelligent Data Acquisition

   • Information Dependent Acquisition (IDA) automatically triggers MS/MS scans
   • Single injection delivers both qualitative and quantitative data

Key Applications

• Clinical Research: Plasma/urine biomarker screening
• Food Safety: Non-targeted pesticide residue analysis
• Drug Metabolism: Complete impurity profiling
• Environmental Monitoring: Emerging contaminant identification

System Configuration

• Ion Source: Turbo V ESI and APCI dual ionization
• Detector: High-sensitivity Multi-Channel Detector (MCD)
• Software: SCIEX OS 1.4 with MasterView data processing

ISO/IEC 17025 certified, the system's SWATH data has been recommended as a gold standard by Nature Methods. It serves as the core analytical platform at leading institutions including the Shanghai Institute of Materia Medica (Chinese Academy of Sciences).