Device built-in

AB SCIEX TripleTOF 7600 High-Resolution LC-MS/MS System Introduction

Core Technological Innovations
The AB SCIEX TripleTOF 7600 is SCIEX's flagship high-resolution liquid chromatography-tandem mass spectrometry (LC-MS/MS) system, integrating two breakthrough technologies: Zeno Trap ion enrichment and Electron-Activated Dissociation (EAD) fragmentation. Featuring a TOF mass analyzer with >60,000 resolution (FWHM at m/z 956), <1 ppm mass accuracy, and 133 Hz MS/MS scan speed, it enables simultaneous high-throughput screening and high-precision quantitative analysis.

Key Technical Features

1. Zeno Trap Technology: Increases TOF duty cycle to 90% through ion pulse focusing, boosting MS/MS sensitivity by 5-20x for enhanced detection of low-abundance compounds (e.g., trace metabolites).
2. EAD Fragmentation: Adjustable electron energy (0-25 eV) enables structural analysis of small molecule isomers (e.g., lipid double bond positioning) and macromolecule PTMs (e.g., protein disulfide bonds) with comprehensive fragment coverage.
3. Dual-Mode Operation: Performs both biologics characterization (e.g., antibody molecular weight determination) and small molecule structural analysis in a single injection, with a dynamic range spanning 5 orders of magnitude.

Primary Applications

• Biopharma: Intact mass analysis of monoclonal antibodies, metabolite identification
• Environmental: Non-targeted screening of emerging contaminants (e.g., PFAS)
• Food Safety: Simultaneous detection of pesticide residues and adulterants
• Clinical Research: Biomarker discovery in serum/urine (>1,000 metabolites identifiable)

System Configuration

• Ion Source: Turbo V Dual Ion Source (ESI/APCI)
• LC Compatibility: Shimadzu Nexera UHPLC series
• Software: SCIEX OS 2.0 with SWATH DIA and MRMHR high-resolution quantitation

This instrument has been adopted by institutions including the Dalian Institute of Chemical Physics (Chinese Academy of Sciences) for combined metabolomics-exposomics studies, simultaneously detecting 1,190 metabolites and 43 xenobiotics per run. ISO/IEC 17025 certified, its data quality meets international standards.

(Note: All technical specifications reflect manufacturer data. "Turbo V", "Zeno Trap", and "SWATH" are SCIEX technologies.)