Device built-in

Product Introduction: Sartorius Flexible Connection Ultrafiltration System Platform (Including UF Holder)

As a global leader in biopharmaceutical purification technology, Sartorius has developed this flexible connection ultrafiltration (UF) system platform as a modular solution for critical downstream processes such as protein concentration and buffer exchange. The system significantly improves the stability and yield of biomolecule processing through innovative flexible connections and intelligent control.

Core Advantages

1. Gentle Fluid Handling System

   • Patented tubing connection technology reduces shear force by **>40%**
   • Equipped with low-pulse peristaltic pumps (flow rate: 0.5–20 L/min)
   • Fully closed flow path design, compliant with Biosafety Level II requirements

2. Modular Ultrafiltration Unit

   • UF holder supports flexible configurations with membrane areas from 0.1 to 5 m²
   • Optional 1–300 kDa molecular weight cut-off (MWCO) membranes (Sartocon® series)
   • Quick-release membrane cassette design (<5 min replacement time)

3. Intelligent Control Platform

   • Integrated pH/conductivity/UV real-time monitoring
   • Optional automated buffer exchange control system
   • Unicorn software compliant with 21 CFR Part 11

Technical Specifications

• Operating pressure: 0–5 bar (expandable to 8 bar)
• Hold-up volume: <200 mL (standard configuration)
• Temperature range: 4–40°C
• CIP resistance: Supports 1M NaOH cleaning cycles

Typical Applications

• Monoclonal antibodies: Bulk concentration & buffer exchange
• Vaccine production: Virus particle diafiltration & purification
• Gene therapy: Plasmid DNA desalting & concentration
• Recombinant proteins: Primary purification of fermentation broth

Service & Support

• Full validation package from lab scale (0.1 m²) to production scale (10 m²+)
• Complete documentation: DQ/IQ/OQ validation files
• Optional automation: Autosampler integration

This platform has been successfully deployed in over 200 global GMP biopharmaceutical production lines, particularly for high-value biologics process development and scale-up. Compared to traditional stainless steel systems, it reduces product loss by 30% and improves batch-to-batch consistency.

For technical inquiries or quotations, please contact Sartorius authorized distributors or visit the official website.

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