Device built-in

908 Devices ZipChip Microfluidic CE-MS Interface System Introduction

Core Technological Innovations
The 908 Devices ZipChip is a revolutionary microfluidic capillary electrophoresis-mass spectrometry interface that integrates traditional CE components (buffer system, separation channel, and electrospray nozzle) into a disposable 2.5×7.5 cm chip. Its unique "separation-ionization" synchronous design completes biomolecule (e.g., proteins, peptides) analysis in <90 seconds—10x faster than conventional LC-MS.

Key Technical Features

1. Ultra-Fast Separation

   • 15 cm microchannel enables <2-minute separations
   • Dual-mode operation: Isoelectric Focusing (IEF) & Zone Electrophoresis (CZE)
   • 50,000 resolution (demonstrated with BSA digests)

2. Seamless MS Integration

   • Direct coupling with Thermo/Sciex/Waters mass spectrometers
   • Nano-ESI flow (50-200 nL/min) enhances ionization efficiency
   • Zero dead-volume design eliminates peak broadening

3. Automated Workflow

   • Hands-free chip loading & buffer exchange
   • Preloaded methods (mAbs, ADCs, rAAV characterization)
   • 0.5-5 μL sample injection capability

Primary Applications

• Biopharma:
  Charge variant analysis (IEF mode)
  Drug-to-antibody ratio (DAR) quantification (CZE mode)
• Gene Therapy:
  AAV capsid purity detection (100x more sensitive than SEC)
• Proteomics:
  Low-abundance PTM peptide enrichment

System Specifications

• Compact dimensions: 30×30×30 cm (world’s smallest CE-MS interface)
• Chip options: 8 types (High-Resolution/High-Throughput/Application-Specific)
• Software: ZipChip Control 2.0 (21 CFR Part 11 compliant)

Awarded the 2024 Pittcon Gold Medal, each chip supports 200+ injections with 60% lower annual costs than traditional CE. Adopted by Moderna and WuXi Biologics for rapid biologics QC.

(Note: "ZipChip" is a registered trademark of 908 Devices. Performance claims based on manufacturer data.)

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