Device built-in

Waters Xevo TQ-S Tandem Quadrupole LC-MS/MS System Product Introduction

Core Technological Innovations
The Waters Xevo TQ-S is a high-performance compact triple quadrupole LC-MS/MS system featuring StepWave XS off-axis ion optics technology. Its dual-stage ion funnel design delivers 10-50x higher sensitivity than conventional instruments with breakthrough signal-to-noise performance. With a mass range of 15-2,000 m/z and 6 orders of linear dynamic range, it reliably detects femtogram-level compounds even in complex matrices (e.g., plasma, tissue homogenates).

Key Technical Features

1. Ultra-Low Maintenance Design:

   • Patented UniSpray ion source enables tool-free replacement in 5 minutes
   • Contamination-resistant ion optics maintain <5% sensitivity loss after 500 consecutive injections

2. Advanced Fragmentation Technology:

   • Seamless switching between MRMHR high-resolution quantitation (>30,000 FWHM) and standard MRM modes
   • Automatic collision cell pressure adjustment (1.0-5.0 mTorr) optimizes fragmentation efficiency

3. Regulatory Compliance:

   • Built-in audit trail and electronic signatures meet FDA 21 CFR Part 11 requirements
   • <15% method transfer variability (platform-to-platform verified)

Primary Applications

• Pharmaceutical R&D:
  Drug metabolite identification (LLOQ: 0.1 pg/mL)
  AAV empty/full capsid ratio analysis (>2σ resolution)
• Food Safety:
  200-pesticide multiresidue screening (GB 23200.121-2021)
  Veterinary drug biomarker tracing (1-10,000 ng/g range)
• Environmental Monitoring:
  Non-targeted PPCPs screening in water (mass accuracy <3 ppm)

System Configuration

• LC Compatibility: ACQUITY UPLC I-Class PLUS
• Detector: High-energy C-Trap with curved linear ion trap
• Software: MassLynx 4.2 (includes QuanOptimize auto method development)

ISO 9001:2015 certified, the 2025 China market base configuration (with autosampler) is priced at ¥1.8-2.2 million RMB. Its compact footprint (55×85 cm) is ideal for space-constrained GMP labs and national testing centers.

(Note: "StepWave", "UniSpray" and "MassLynx" are Waters trademarks. Performance claims reflect manufacturer data.)

For GMP validation packages or application-specific configurations, please consult your local Waters representative.