Device built-in
Agilent 1260 Series Gel Permeation Chromatography System
The Agilent 1260 Series Gel Permeation Chromatography (GPC) System is a high-performance polymer analysis platform developed by Agilent Technologies, integrating advanced liquid chromatography technology with specialized GPC/SEC solutions. Featuring a modular design, it supports a full range of requirements from routine quality control to cutting-edge research applications, providing an authoritative analytical tool for polymer characterization.
Core Components and Technological Innovations
The system is equipped with a 1260 Infinity II high-performance pump capable of withstanding pressures up to 600 bar. Its intelligent flow rate calibration enables precise flow control at 0.001 mL/min. The column thermostat offers a broad temperature range from 10°C above ambient to 85°C, with an optional high-temperature module extending the upper limit to 220°C, suitable for analyzing hard-to-dissolve polymers like polyolefins. The detector array includes a refractive index detector, a multi-wavelength UV detector, and can integrate light scattering detectors and a viscometer for absolute molecular weight determination.
Key Performance Highlights
Molecular weight measurement range: 200 Da to 1×10^8 Da, with a resolution of 15,000 theoretical plates.
Retention time precision (RSD): better than 0.1%; molecular weight reproducibility error: less than 3%.
High-temperature models feature a fully inert flow path resistant to strong polar solvents like DMF and trichlorobenzene.
Application Scenarios
Widely used for analyzing molecular weight distribution of polyethylene in the petrochemical industry; monitoring copolymer composition changes in polymer materials; and analyzing protein aggregates in the biopharmaceutical sector. The system's GPC/SEC software offers 21 calibration curve fitting algorithms and supports compliance verification per pharmacopeia requirements.
System Features
Autosampler supports 96-well sample plates with an injection precision of 0.25%.
Integrated online degasser with 4 channels.
Optional multi-angle light scattering detector for absolute molecular weight determination.
Compliance software package meeting FDA 21 CFR Part 11 regulations.
With its modular expandability, the system can be upgraded to a preparative three-dimensional orthogonal characterization platform, solidifying its role as a core analytical tool in polymer research laboratories. Its exceptional reproducibility and scalability ensure its continued critical importance in both academic research and industrial applications.