Device built-in

Instrument Overview

The Malvern ZetaSizer Pro is a high-end nanoparticle characterization system developed by Malvern Panalytical (UK), integrating three core technology platforms: dynamic light scattering (DLS), electrophoretic light scattering (ELS), and static light scattering (SLS). Launched in 2023, it represents the highest technical standard in the field of nanoparticle characterization, providing precise measurements of key parameters including particle size distribution, zeta potential, and molecular weight.

Core Technical Features

1. Fully Automated Measurement System

   Equipped with an intelligent temperature control system (4-90°C) and an auto-sampler supporting continuous measurement of up to 384 samples. The APT (Automated Programmable Titration) technology enables automated operations such as pH titration and reagent addition, significantly improving experimental efficiency.

2. Enhanced Optical System

   Features the latest HELOS laser diffraction optical platform and Aviv 4 detector, offering 60% higher sensitivity than previous models. The patented NIBS (Non-Invasive Backscatter) optical design supports dual-angle detection at 173° and 13°, enabling measurement of a broad size range from 0.3 nm to 10 μm, with a concentration range of 0.1 ppm to 40% w/w.

3. Multi-Parameter Simultaneous Measurement

   The exclusive M3-PALS technology allows simultaneous acquisition of particle size, zeta potential, and mobility data in a single measurement, eliminating errors caused by sample transfer. Temperature control accuracy reaches ±0.1°C, supporting real-time correlation analysis of multiple parameters such as ionic strength and pH.

Application Areas

1. Biopharmaceuticals

   Suitable for characterizing biological nanoparticles including liposomes, exosomes, and viral vectors. It detects protein aggregation and evaluates formulation stability. Complies with FDA 21 CFR Part 11 regulations and meets GMP requirements.

2. Nanomaterials

   Precisely characterizes the dispersity and aggregation state of materials such as carbon nanotubes, quantum dots, and metal nanoparticles, providing critical data for quality control.

3. Energy and Environmental Protection

   Used for particle size control of battery slurries and catalysts, as well as monitoring and analysis of nanoparticles in environmental pollution.

Software and Intelligence

The instrument is equipped with ZS Xplorer professional software, featuring:

• Guided operation interface with one-click Standard Operating Procedures (SOPs)

• Real-time data quality indication system for automatic reliability assessment

• AI-assisted data analysis capable of automatically identifying multimodal distributions and outliers

• Full support for data tracking and audit trail functions

Technical Advantages

1. Ultra-High Sensitivity: Detection capability for protein samples as low as 0.1 mg/mL.

2. Exceptional Repeatability: Particle size measurement accuracy of ±0.1 nm, zeta potential repeatability of ±2 mV.

3. Comprehensive Protection: Complete biosafety protection options for handling biohazardous samples.

4. Smart Connectivity: Supports integration with LIMS systems and remote monitoring capabilities.

The instrument adopts a modular design, allowing the selection of various accessories such as auto-titrators and multi-angle detectors based on research needs. Its outstanding performance and intelligent design make it an ideal choice for nanotechnology research, drug development, and industrial quality control, providing researchers and engineers with comprehensive and accurate solutions for nanomaterial characterization.

(Note: This description is based on typical technical features of this instrument series. Specific parameters may vary depending on actual configuration.)