Device built-in

Comprehensive Introduction to AB Sciex ExionLC AD Liquid Chromatography System

Core Performance and Technical Features

The AB Sciex ExionLC AD is an ultra-high performance liquid chromatography (UHPLC) system specifically designed for demanding analytical requirements, with its 1300 bar (18,500 PSI) ultra-high pressure capability enabling it to handle nearly all advanced analytical methods and workflows. This modular system is particularly suitable for small-to-medium sized laboratories in fields such as food/environmental testing, clinical research, and forensic science. The solvent delivery system offers a flow rate range of 0.0001 to 3.0000 mL/min (up to 10.0 mL/min at 220 bar), supporting separation for columns with inner diameters from 1.0 to 4.6mm.

The ExionLC AD's autosampler features a four-solvent flush design with carryover below 0.0015% (15 ppm). It provides an injection volume range of 0.1 to 50.0 μL, injection precision RSD≤0.25% (5 μL injection), and a rapid cycle time of just 14 seconds. The standard configuration accommodates 2 trays, supporting standard or deep-well 96-well plates along with 105 1.5 mL vials, with temperature-controlled environment (as low as 4°C) to protect thermally sensitive samples.

System Design and Innovative Technology

The ExionLC AD employs a bottom-up design philosophy to deliver optimal UHPLC performance under rigorous analytical conditions. Its newly designed heated column compartment offers a temperature range of 5°C to 150°C, enabling exploration of higher column temperatures and unusual chromatographic phases. Optional solvent switching valve modules provide greater flexibility, while column switching modules simplify complex separations or method development strategies.

The system's gradient delay volume is optimized to 120 μL (with 20 μL mixer), with flow rate precision RSD<0.06% and flow rate accuracy of ±1%, ensuring accurate and stable gradient elution. Backed by SCIEX's 40+ years of LC-MS innovation and service support, the ExionLC AD is ideally suited for analytical laboratories requiring top-tier LC-MS performance.

Application Fields and Expandability

The ExionLC AD liquid chromatography system finds wide application in multiple fields:

• Pharmaceutical/Biopharmaceutical: Drug screening, candidate drug quality control, pharmacokinetic studies
• Life Science Research: Proteomics, metabolomics, lipidomics and other multi-omics research
• Food Safety and Environmental Testing: Trace analysis of pesticide residues, food additives, environmental pollutants
• Forensic Science: Toxicant screening, drug abuse detection

The system's expandability is one of its standout features. Users can increase sample capacity by adding ExionLC sample tray switching modules (12 plates/648 vials) or ExionLC AD multi-plate autosamplers (6 plates/324 vials). Additionally, UV-Vis or PDA detectors can be incorporated to add ultraviolet absorption detection capabilities. This modular design allows the ExionLC AD to adapt to future needs, ensuring long-term value for laboratory investments.

Physical Parameters and System Advantages

The ExionLC AD system measures 560×830×560 mm (W×H×D) and weighs 76 kg, with power requirements of 100-240 VAC, making it suitable for most laboratory spaces. The accompanying intelligent software provides an intuitive user interface and powerful method development tools, streamlining the entire process from method creation to data processing.

The ExionLC AD demonstrates excellent compatibility with SCIEX mass spectrometers. Through specialized interface technology and data transfer protocols, it enables rapid, lossless sample transfer and real-time data acquisition, enhancing the overall analytical system's sensitivity and dynamic range. This seamless LC-MS coupling capability makes it an ideal choice for modern analytical laboratories, particularly research institutions pursuing high-resolution and high-throughput analysis.