Device built-in

Agilent GC-MS System: The Perfect Combination of 5975 Inert XL MSD and 6890N GC

System Overview

The Agilent Gas Chromatography-Mass Spectrometry (GC-MS) system, comprising the 5975 Inert XL Mass Spectrometer Detector (MSD) and 6890N Gas Chromatograph (GC), is a high-performance qualitative and quantitative analysis platform. Widely used in environmental monitoring, food safety, pharmaceutical analysis, petrochemicals, forensic toxicology, and life sciences, this system integrates high-resolution chromatographic separation with high-sensitivity mass spectrometry detection, enabling precise analysis of trace compounds in complex samples. It delivers reliable data support for both research and industrial testing.

Core Components and Technological Innovations

1. 5975 Inert XL Mass Spectrometer Detector (MSD)

   High-Sensitivity Detection: Features an inert ion source and quadrupole mass analyzer, minimizing adsorption of reactive compounds and enhancing detection sensitivity—especially for adsorptive or thermally unstable compounds (e.g., pesticide residues, volatile organic compounds).
   • Wide Dynamic Range: Mass range of 1.2–1050 Da, capable of detecting both low- and high-concentration components simultaneously, reducing sample preparation requirements.
   • Turbo Molecular Pump System: Ensures a stable high-vacuum environment for consistent and reproducible MS detection.
   • Smart Tuning and Calibration: Supports AutoTune and NIST library matching, simplifying method development.

2. 6890N Gas Chromatograph (GC)

   • Precise Separation Capability: Equipped with Electronic Pneumatic Control (EPC) and multi-mode injection systems (e.g., split/splitless), ideal for complex matrix separation.
   • Expandable Detector Options: Compatible with additional detectors such as Flame Ionization Detector (FID) and Electron Capture Detector (ECD), meeting diverse analytical needs.
   • Efficient Oven System: Heating rates up to 120°C/min, enabling rapid GC analysis and shorter experimental cycles.

3. Intelligent Software and Data System

   • Agilent MassHunter Workstation: Provides end-to-end solutions from data acquisition and processing to report generation, supporting compound screening, quantitative analysis, and spectral library searching.
   • Regulatory Compliance: Meets GMP/GLP requirements, making it suitable for pharmaceutical and quality control applications.

Key Application Scenarios

1. Environmental Monitoring

   • Trace Pollutant Analysis: Detection of polycyclic aromatic hydrocarbons (PAHs) in air or organochlorine pesticides in water, with detection limits as low as ppt levels.
   • Volatile Organic Compounds (VOCs): Coupled with headspace or purge-and-trap sampling, accurately measures benzene derivatives and aldehydes/ketones in soil or wastewater.

2. Food Safety and Agricultural Testing

   • Pesticide Residue Screening: Rapid identification of hundreds of pesticides using the NIST library, complying with EU and China GB standards.
   • Food Additives and Flavor Compounds: Analysis of plasticizers in beverages or volatile components in flavorings.

3. Pharmaceutical and Clinical Research

   • Drug Metabolite Analysis: Detection of drugs and their metabolites in blood/urine via derivatization techniques.
   • Impurity Identification: Control of genotoxic impurities (e.g., nitrosamines) in APIs and formulations.

4. Petrochemical and Materials Science

   • Hydrocarbon Composition Analysis: Quantification of aromatics and olefins in gasoline or additive degradation products in lubricants.
   • Polymer Volatiles: Detection of monomer residues or pyrolysis products in plastics.

System Advantages and Industry Value

• High Reliability: Known for low maintenance and long lifespan, with critical components (e.g., ion source) made of inert materials to minimize contamination and wear.
• Flexible Expandability: Compatible with Headspace Sampler (HS) and Thermal Desorption (TD) systems, accommodating solid, liquid, and gas samples.
• High-Throughput Analysis: Combined with the 7683B Autosampler, enables unattended continuous operation, improving lab efficiency.
• Global Compliance Support: Meets international standards such as EPA and ISO (e.g., EPA 8270, ISO 17025), facilitating global data recognition.

Conclusion

The Agilent 5975 Inert XL MSD and 6890N GC system represents the maturity and innovation of GC-MS technology. With its high sensitivity, precise separation, and intelligent operation, it serves as the gold standard for complex sample analysis. Whether for scientific research or industrial quality control, this system delivers efficient, accurate, and compliant solutions, empowering users to meet increasingly stringent analytical challenges.