Device built-in

Introduction to the Thermo Fisher Scientific Corona Veo Charged Aerosol Detector (CAD) (2018 Model) Paired with the Peak 1010 Nitrogen Generator

1. Product Overview

The Thermo Fisher Scientific Corona Veo Charged Aerosol Detector (CAD) (2018 model) is a high-performance, universal detector for HPLC/UHPLC systems. It utilizes Charged Aerosol Detection (CAD) technology, making it ideal for highly sensitive detection of compounds with weak or no UV absorption. When paired with the Peak 1010 Nitrogen Generator, it ensures stable, high-purity nitrogen supply (99.999%) for optimal CAD performance.

2. Key Technical Features

(1) Corona Veo CAD Detector Highlights

• High Sensitivity: Detection limits (LOD) as low as picogram (pg) levels, suitable for trace analysis of pharmaceuticals, sugars, lipids, polymers, etc.
• Universal Detection: Works with nearly all non-volatile and semi-volatile compounds, overcoming the limitations of UV detectors.
• Wide Dynamic Range (>4 orders of magnitude): Offers better linearity than ELSD (Evaporative Light Scattering Detector), ideal for quantitative analysis.
• Smart Control: Compatible with Thermo Fisher’s Chromeleon Chromatography Data System for automated method optimization and data management.
• Low Maintenance: Optimized nebulizer and collector design reduces contamination and cleaning frequency.

(2) Peak 1010 Nitrogen Generator Key Features

• High-Purity Nitrogen Output (99.999%): Meets the stringent gas purity requirements of CAD detectors, eliminating interference from impurities.
• Stable Gas Supply (adjustable 0-100 psi): Built-in pressure regulation and flow control ensure consistent detector signal stability.
• Low Operating Costs: More economical than gas cylinders in the long run, with no need for frequent replacements.
• Compact & Quiet Design: Noise levels below 50 dB, space-saving, and suitable for lab environments.

3. Typical Applications

• Pharmaceutical Industry: Impurity profiling, excipient analysis, and biopharmaceutical purity assessment.
• Food & Nutraceuticals: Quantification of sugars, amino acids, fatty acids, vitamins, and other non-UV-active compounds.
• Environmental Testing: Detection of pesticide residues, environmental pollutants (e.g., PFAS), and trace contaminants.
• Research & Biotechnology: Lipidomics, metabolomics, and polymer molecular weight distribution analysis.

4. System Compatibility & Ease of Use

• Seamless HPLC/UHPLC Integration: Compatible with Thermo Fisher’s Vanquish and UltiMate series, as well as other brands (e.g., Agilent, Waters).
• Plug-and-Play Operation: The Peak 1010 Nitrogen Generator connects easily via tubing and starts supplying gas immediately without complex setup.
• Low Maintenance: The CAD detector only requires periodic nebulizer cleaning, while the nitrogen generator needs annual filter replacement.

5. Market Positioning & User Feedback

• Positioning: The 2018 Corona Veo CAD is a mid-to-high-end detector, ideal for labs requiring high sensitivity and broad applicability.
• User Reviews:
  • Pros: Excellent detection stability, especially for complex matrices; the nitrogen generator is reliable and significantly reduces operational costs.
  • Cons: Higher initial investment, but long-term cost efficiency surpasses ELSD.

6. Conclusion

The Thermo Fisher Corona Veo CAD + Peak 1010 Nitrogen Generator combination is an excellent choice for HPLC analysis, particularly for high-sensitivity detection of non-UV-absorbing compounds. Its versatility, low maintenance, and stable performance make it widely adopted in pharmaceuticals, food, environmental testing, and research. For labs with sufficient budget and long-term analytical needs, this setup offers strong cost-effectiveness.

For detailed technical specifications or application notes, refer to Thermo Fisher’s official documentation or authorized distributors.