Device built-in

Molecular Devices SpectraMax M Series Multi-Mode Microplate Reader 

The Molecular Devices SpectraMax M Series is a benchmark in multi-mode microplate readers, renowned for its modular design, high sensitivity, and broad application range. This series includes models such as the M2e, M3, M4, and M5e, catering to diverse needs from basic research to drug screening. Its core technologies cover absorbance (200–1000 nm), fluorescence intensity (250–850 nm), time-resolved fluorescence (TRF), fluorescence polarization (FP), and luminescence detection modes.

Key Features

1. Optical System: Equipped with a dual monochromator design, it enables wavelength adjustment in 1 nm increments without the need for filters, ensuring high-precision spectral scanning and low background interference. For example, the M5e model features an ultra-cooled PMT detector, achieving picomolar (pM) sensitivity for weak signal detection.
2. Modular Expandability: Users can upgrade functionalities based on experimental needs, such as AlphaScreen/AlphaLISA detection for the M5e or Western Blot and cellular imaging modules for the M4.
3. Automation Compatibility: Some models (e.g., iD5) integrate robotic arm interfaces and barcode recognition, supporting high-throughput screening workflows.

Typical Applications

• Molecular Biology: Nucleic acid/protein quantification (A260/A280), fluorescent dye analysis (e.g., PicoGreen).
• Drug Discovery: Enzyme kinetics (Km/Vmax), small-molecule inhibitor screening (IC50), and cytotoxicity assays (MTT, CellTiter-Glo).
• Immunology: ELISA, TRF-based immunoassays (e.g., DELFIA).

Software & Maintenance
The accompanying SoftMax Pro software offers 21 CFR Part 11 compliance, featuring preloaded experiment templates, multi-parameter curve fitting, and data audit capabilities. For maintenance, the modular design (e.g., replaceable xenon lamps and PMTs) and annual calibration services ensure long-term instrument stability.

Conclusion
With its flexible configuration, high-sensitivity optical system, and powerful software support, the SpectraMax M Series is an ideal choice for life sciences, pharmaceuticals, environmental monitoring, and other fields—particularly suited for laboratories requiring multi-mode detection and standardized data management.