Device built-in

Shimadzu LC-20AT High Performance Liquid Chromatograph Technical Overview (2025 Edition)

Core Configuration
The Shimadzu LC-20AT, part of the Prominence series, features a tandem dual-plunger pump design (47μL primary + 23μL secondary pump heads) with flow rate range of 0.001-10.000 mL/min and 40MPa pressure limit. Capable of binary/ternary high-pressure mixing with ±1% composition accuracy. Standard configuration includes DGU-20A in-line degasser and CBM-20A system controller, expandable with SPD-M20A diode array detector (190-800nm), RF-10AXL fluorescence detector, and evaporative light scattering detector.

Technological Innovations

1. High-Pressure Gradient Mixing: Independent dual-pump flow control enables precise solvent ratio adjustment for complex sample separation.
2. Intelligent Detection System:
   • SPD-M20A detector employs 512-diode array with 1.2nm high-resolution mode (<0.3×10⁻⁵ AU baseline noise)
   • RF-10AXL fluorescence detector offers 10x higher sensitivity than UV for PAHs and amino acids
3. Automated Operation: SIL-20A autosampler handles 0.1-100μL injections (RSD <0.3%) with CTO-20A column oven (4-100℃) for optimized separation

Applications

• Pharmaceuticals: Drug metabolite analysis (LOD: 0.1pg/mL)
• Food Safety: 200-pesticide multi-residue screening (GB 23200.121-2021 compliant)
• Environmental: Non-target PPCPs screening in water (<3ppm mass accuracy)

Service & Compliance

• 21 CFR Part 11 compliant software with audit trail
• Base configuration priced at ¥198,000 including installation and training

(Maintenance Note: Recommend turbo pump oil replacement every 2,000 hours. Mobile phase requires 0.45μm filtration and degassing)

Optional Modules

• LCMS-2020 mass spectrometer interface
• 2D-LC conversion kit
• GMP validation package

For application notes or regional service, contact Shimadzu-certified engineers.