Device built-in

Agilent 6470 Triple Quadrupole LC-MS/MS System Technical Overview

Core Technological Innovations
The Agilent 6470 system features Dual Agilent Jet Stream ionization technology, enhancing ionization efficiency by 3-5x through axial thermal gradient focusing, coupled with an iFunnel six-stage ion funnel achieving >90% ion transfer efficiency. With a mass range of 15-3,200 m/z and scan speeds up to 12,000 Da/s, it simultaneously monitors 500 MRM transitions with a 6-order dynamic quantitative range (1 pg-1 μg/mL), meeting ultra-trace detection requirements.

Breakthrough Performance

1. Ultra-Fast Polarity Switching: 25ms polarity switching (30% faster than predecessors), ideal for complex matrices like metabolomics
2. Smart Fragmentation: Dynamic linear collision cell (0.1-5.0 mTorr) auto-optimizes fragmentation energy for different m/z ions
3. Regulatory Compliance: MassHunter workstation meets 21 CFR Part 11 requirements with full audit trail and e-signature capabilities

Key Applications

• Pharmaceutical R&D:
  Drug metabolite identification (LLOQ: 0.1 pg/mL)
  AAV empty/full capsid ratio analysis (>2σ resolution)
• Food Safety:
  200-pesticide multi-residue screening (GB 23200.121-2021)
  Veterinary drug biomarker tracing (1-10,000 ng/g linear range)
• Environmental Monitoring:
  Non-targeted PPCPs screening in water (mass accuracy <3 ppm)

System Configuration

• LC Compatibility: 1290 Infinity II UHPLC system
• Detector: High-energy C-Trap with curved linear ion trap
• Software: MassHunter 10.0 (includes QuanOptimize auto method development)

ISO 9001:2015 certified, the 2025 China base configuration (with autosampler) is priced at ¥2.8-3.5 million RMB. Its compact footprint (55×85 cm) is optimized for space-constrained GMP labs and national testing centers.

(Note: Requires high-purity nitrogen generator; turbo pump oil replacement recommended every 2,000 operating hours.)

Optional Modules

• High Sensitivity ion optics upgrade kit
• IonKey MS interface for microflow applications
• GMP validation service package

For method development support or regional service inquiries, contact Agilent certified application specialists.