Device built-in

SCIEX Triple Quad 7500 QTRAP System Introduction

The SCIEX Triple Quad 7500 QTRAP system is a globally leading hybrid triple quadrupole-linear ion trap mass spectrometer that perfectly combines the high-sensitivity quantitative capability of triple quadrupole technology with the qualitative analysis function of linear ion trap, providing ultra-high sensitivity and structural confirmation for complex sample analysis.

Core Technical Features

The system adopts an innovative triple quadrupole-linear ion trap hybrid configuration, comprising three key modules:

1. Ion Source System:

• Standard OptiFlow™ Pro ion source compatible with flow rates from 1 µL/min to 3 mL/min
• Optional ESI and APCI ionization modes
• Innovative E Lens™ technology enhances ion transmission efficiency with significant sensitivity improvement

2. Mass Analyzer:

• First quadrupole (Q1) mass range: 5-2,000 Da
• Second quadrupole (Q2) as collision cell with adjustable energy (0-120 eV)
• Third quadrupole (Q3) switchable to linear ion trap mode

3. Detection System:

• High-energy detector with dynamic range up to 6 orders of magnitude
• Polarity switching time <5 milliseconds
• Acquisition speed up to 800 MRM/sec

Performance Advantages

The SCIEX Triple Quad 7500 QTRAP offers several groundbreaking technologies:

1. QTRAP Hybrid Scanning Functions:

• MRM³ scanning provides better specificity and quantitative performance
• Enhanced product ion scanning (EPI) obtains high-quality MS/MS spectra
• Enhanced full scan function detects unknown analytes

2. Ultra-High Sensitivity:

• D Jet™ ion guide technology captures more ions
• Detection limit at fg level (reserpine)
• Suitable for trace substance analysis in biological samples

3. High-Throughput Analysis:

• MassGuard™ technology reduces contamination risk
• DJet+ removable inlet assembly facilitates maintenance
• Compatible with high-throughput laboratory workflows

Key Application Areas

With its outstanding performance, the system excels in:

• Proteomics: Protein identification, post-translational modification analysis
• Metabolomics: Global small molecule analysis
• Pharmaceutical Research: Drug metabolite identification, impurity analysis
• Food Safety: Pesticide screening, adulterant detection
• Environmental Analysis: Emerging contaminant monitoring

In lipidomics research, the system has been successfully applied to analyze lipid metabolic pathways in cavefish, with related findings published in Molecular Biology and Evolution (IF:16.3). In clinical studies, it can identify over 4,000 plasma proteins within 30 minutes.

The SCIEX Triple Quad 7500 QTRAP represents the pinnacle of hybrid mass spectrometry technology. Its innovative hardware design and intelligent workflow provide comprehensive solutions for complex sample analysis, making it the ideal choice for modern analytical laboratories.