Device built-in

Thermo Scientific TSQ Altis Triple Quadrupole Mass Spectrometry System

The Thermo Scientific TSQ Altis is a high-performance triple quadrupole mass spectrometry system developed by Thermo Fisher Scientific, specifically designed for trace-level quantitative analysis in complex matrices. Featuring innovative Active Ion Management Plus (AIM+) technology, this system demonstrates exceptional performance in proteomics, environmental monitoring, pharmaceutical research, and clinical studies.

Core Technical Features

The TSQ Altis incorporates several groundbreaking technological innovations across three key modules:

1. Enhanced Ion Transmission System:

• Utilizes AIM+ technology to optimize ion transmission path from source to detector, eliminating major noise sources and significantly improving signal-to-noise ratio
• Segmented quadrupole design with adjustable collision energy (0-120 eV) supports generation of more abundant secondary fragments
• Innovative curved ion transfer path with neutral particle deflector effectively filters interference and extends maintenance intervals

2. Ultra-High Sensitivity Detection:

• Mass range: 5-2000 m/z with resolution up to 0.2 Da FWHM
• SRM mode scanning speed up to 600 times/sec with 5ms polarity switching
• Detection limits at fg level (on-column), with signal enhancement technology improving low-abundance component detection by 10x

3. Intelligent Workflow:

• Deep integration with TraceFinder software platform simplifies entire workflow from method development to report generation
• AutoSRM (Automated Scheduled SRM) and intelligent diagnostics system significantly improve method development efficiency
• Compliant with 21 CFR Part 11 regulations to ensure data integrity

Performance Advantages

The TSQ Altis excels in several critical performance metrics:

1. Outstanding Quantitative Performance:

• Achieves 4 orders of magnitude linear range for protein biomarker analysis with LOQ reaching 1.67 amol
• Intra-assay precision CV<5% for clinical 25-hydroxyvitamin D testing, meeting precision medicine requirements
• Dynamic range >10⁶ with correlation coefficient R²>0.99, suitable for wide concentration range sample analysis

2. Broad Application Scope:

• Environmental analysis: Direct injection detection of 17 perfluorinated compounds (PFCs) in water, meeting EPA 537 regulation requirements (detection limits 0.53-6.5 ng/L)
• Food safety: Simultaneous monitoring of >300 pesticide residues, compliant with EU SANTE/11813/2017 standards
• Proteomics: Seamless transition from discovery (Orbitrap) to verification (TSQ Altis)

3. Excellent System Stability:

• Mass axis stability ≤0.1 Da/24 hours ensures long-term quantitative accuracy
• Maintains high reliability under intensive continuous analysis, ideal for high-throughput laboratories

Through its innovative hardware design and intelligent software platform, the Thermo Scientific TSQ Altis elevates laboratory productivity and quantitative analysis reliability to new heights, making it the ideal tool for precise quantification of trace substances in complex matrices. Its outstanding sensitivity, stability, and user-friendliness make it particularly suitable for demanding applications such as protein biomarker development and environmental pollutant monitoring.