Device built-in

Thermo Scientific TSQ Quantis Triple Quadrupole Mass Spectrometry System Introduction

The Thermo Scientific TSQ Quantis represents a next-generation high-performance triple quadrupole mass spectrometry system, specifically designed for high-sensitivity quantitative analysis. Featuring innovative ion optics design and intelligent workflows, this system demonstrates exceptional performance in drug metabolism, environmental monitoring, food safety, and clinical research applications.

Core Technical Features

The TSQ Quantis incorporates several groundbreaking technological innovations across three key modules:

1. Ion Source System:

• Standard HESI-II ion source compatible with multiple ionization modes (ESI, APCI)
• Advanced ion focusing technology provides 3-5x sensitivity improvement over previous generations
• Temperature range: 50-600°C for diverse compound analysis
• Patented ion beam focusing technology minimizes matrix interference

2. Mass Analyzer:

• Mass range: 10-3,000 m/z with adjustable resolution (0.2-2.5 FWHM)
• Segmented quadrupole technology with adjustable collision energy (0-120 eV)
• Ultra-fast scanning speed up to 12,000 Da/sec with 10ms polarity switching

3. Detection System:

• High dynamic range detector
• Linear range >10⁶ with correlation coefficient R²>0.99
• Acquisition rate reaching 500 SRM channels/sec

Performance Advantages

The TSQ Quantis offers several industry-leading technical specifications:

1. Ultra-High Sensitivity:

• SRM mode detection limits at fg level (on-column)
• Signal-to-noise enhancement technology improves low-abundance component detection by 10x
• Demonstrates exceptional baseline stability with 1 pg/mL pure solution samples

2. Intelligent Operation:

• Automated method optimization (AutoSRM)
• Smart diagnostics and calibration ensure long-term stability
• Compliant with 21 CFR Part 11 regulations

3. Exceptional Durability:

• Maintains high reliability under intensive continuous analysis
• Delivers accurate data even with high-matrix samples (biological, food)
• Innovative vacuum system design reduces maintenance requirements

Key Applications

The TSQ Quantis demonstrates outstanding performance in:

• Clinical Research: Newborn screening, vitamin detection, hormone analysis
• Pharmaceutical Development: Pharmacokinetic studies, bioequivalence evaluation, metabolite identification
• Food Safety: Pesticide residues, veterinary drug residues, mycotoxin detection
• Environmental Monitoring: Analysis of persistent organic pollutants in water and soil
• Forensic Toxicology: Drug abuse screening, quantitative toxicant analysis

For clinical 25-hydroxyvitamin D testing, the TSQ Quantis completes single-sample analysis in 3 minutes with intra-assay precision CV<5%. In pesticide multi-residue analysis, the system simultaneously monitors >300 pesticides, meeting EU SANTE/11813/2017 standards.

The Thermo Scientific TSQ Quantis represents the forefront of triple quadrupole mass spectrometry technology, providing laboratories with efficient and reliable solutions through its innovative ion optics design and intelligent workflows, making it the ideal tool for precise quantification of trace substances in complex matrices.