Device built-in

Comprehensive Analysis of Thermo Scientific TSQ Altis Triple Quadrupole Mass Spectrometry System

The Thermo Scientific TSQ Altis represents a next-generation high-performance triple quadrupole mass spectrometry system, delivering exceptional sensitivity and reliable reproducibility for trace substance analysis in complex matrices through innovative ion optics design and intelligent workflows. This advanced analytical platform excels in clinical diagnostics, pharmaceutical development, food safety, and environmental monitoring applications.

Core Technical Features

The TSQ Altis incorporates innovative Advanced Active Q Technology, significantly improving ion transmission efficiency and stability through novel quadrupole design and intelligent control systems. The system comprises three core modules:

1. Ion Source System:

• Standard HESI-II ion source compatible with multiple ionization modes (ESI, APCI)
• Innovative ion focusing technology provides 3-5x sensitivity improvement over previous generations
• Temperature range: 50-600°C for diverse compound properties
• Patented ion beam focusing technology reduces matrix interference

2. Mass Analyzer:

• Mass range: 10-3,000 m/z with adjustable resolution (0.2-2.5 FWHM)
• Segmented quadrupole technology with adjustable collision energy (0-120 eV)
• Ultra-fast scanning speed up to 12,000 Da/sec with 10ms polarity switching

3. Detection System:

• High dynamic range detector
• Linear range >10⁶ with correlation coefficient R²>0.99
• Acquisition rate reaching 500 SRM channels/sec

Performance Advantages

The TSQ Altis boasts several industry-leading technical specifications:

1. Ultra-High Sensitivity:

• SRM mode detection limits at fg level (on-column)
• Signal-to-noise enhancement technology improves low-abundance component detection by 10x
• Demonstrates exceptional baseline stability with 1 pg/mL pure solution samples

2. Intelligent Operation:

• Automated method optimization (AutoSRM)
• Smart diagnostics and calibration ensure long-term stability
• Compliant with 21 CFR Part 11 regulations

3. Exceptional Durability:

• Maintains high reliability under intensive continuous analysis
• Delivers accurate data even with high-matrix samples (biological, food)
• Innovative vacuum system design reduces maintenance requirements

Key Applications

The TSQ Altis demonstrates outstanding performance in:

• Clinical Diagnostics: Newborn screening, vitamin detection, hormone analysis
• Pharmaceutical Development: Pharmacokinetic studies, bioequivalence evaluation, metabolite identification
• Food Safety: Pesticide residues, veterinary drug residues, mycotoxin detection
• Environmental Monitoring: Analysis of persistent organic pollutants in water and soil
• Forensic Toxicology: Drug abuse screening, quantitative toxicant analysis

For clinical 25-hydroxyvitamin D testing, the TSQ Altis completes single-sample analysis in 3 minutes with intra-assay precision CV<5%. In pesticide multi-residue analysis, the system simultaneously monitors >300 pesticides, meeting EU SANTE/11813/2017 standards.

The Thermo Scientific TSQ Altis represents the forefront of triple quadrupole mass spectrometry technology, providing laboratories with efficient and reliable solutions through its innovative ion optics design and intelligent workflows, making it the ideal tool for precise quantification of trace substances in complex matrices.