Device built-in

Comprehensive Analysis of Shimadzu LCMS-8060 Ultra-Fast Triple Quadrupole LC/MS System

The Shimadzu LCMS-8060 represents a globally leading ultra-fast triple quadrupole liquid chromatography-mass spectrometry system, delivering breakthrough sensitivity and speed for trace substance analysis in complex matrices through revolutionary ion optics technology and ultra-high-speed scanning capabilities. This advanced analytical platform excels in clinical research, food safety, environmental monitoring, and other demanding applications.

Core Technical Features

The LCMS-8060 incorporates the innovative UF-Qarray ion optics system, significantly improving ionization efficiency and focusing capability through newly designed ion guidance technology, achieving sensitivity more than 3 times higher than the LCMS-8050. The system comprises three core modules:

1. Ion Source System:

• Standard UniSpray ion source compatible with multiple ionization modes (ESI, APCI)
• Enhanced ionization efficiency technology reduces matrix interference
• Temperature range: 100-600°C for diverse compound properties

2. Mass Analyzer:

• Mass range: 2-2,000 m/z with 0.7 u resolution (FWHM)
• T-Wave collision cell technology with adjustable collision energy (0-120 eV)
• Ultra-fast scanning speed up to 30,000 u/sec with 5ms polarity switching

3. Detection System:

• High-energy dynode electron multiplier
• Dynamic range >10⁶ with linear correlation coefficient R²>0.99
• Acquisition rate reaching 555 MRM channels/sec

Performance Advantages

The LCMS-8060 boasts several industry-leading technical specifications:

1. Ultra-High Sensitivity:

• MRM mode detection limits at fg level (on-column)
• Signal-to-noise enhancement technology improves low-abundance component detection by 10x
• Demonstrates exceptional baseline stability with 100 pg/mL pure solution samples

2. Ultra-Fast Analysis:

• 30,000 u/s ultra-high-speed scanning (UFScanning)
• 5ms polarity switching speed (UFSwitching), 3x faster than conventional systems
• Simultaneous measurement of 65 compounds within 400ms cycle time

3. Exceptional Durability:

• Maintains high reliability under intensive continuous analysis
• Delivers accurate data even with high-matrix samples (biological, food)
• Automatic diagnostics and calibration ensure long-term stability

Key Applications

The LCMS-8060 demonstrates outstanding performance in:

• Clinical Research: Challenging biomarker detection (e.g., catecholamines), completing plasma sample analysis in 12 minutes
• Food Safety: Simultaneous screening of 105 pesticide residues with detection limits reaching 300pg/mL
• Environmental Monitoring: Trace analysis of persistent pollutants like perfluoroalkyl substances (PFAS)
• Biopharmaceuticals: Lipid mediator analysis covering dynamic range from sub-nM to μM
• Metabolomics: Precise quantification of low-level metabolites such as phosphatidylcholine

At Vanderbilt University, the LCMS-8060 significantly improved analytical selectivity for 14 antiepileptic drugs compared to conventional LC-MS/MS. In environmental water sample PFAS analysis, its high sensitivity and anti-matrix interference capability provide reliable data for pollution assessment.

The Shimadzu LCMS-8060 represents the pinnacle of triple quadrupole mass spectrometry technology, setting new standards for trace analysis in complex matrices through its innovative ion optics design and ultra-high-speed scanning capabilities, making it the ideal choice for high-end laboratories pursuing ultimate performance.