Device built-in

Comprehensive Analysis of Waters Xevo TQS Triple Quadrupole Mass Spectrometry System

The Waters Xevo TQS is a high-performance triple quadrupole mass spectrometer specifically designed for precise quantitative analysis. Combining exceptional sensitivity with outstanding stability, it has become the preferred analytical platform for clinical research, food safety, environmental monitoring, and pharmaceutical development.

System Configuration and Core Technologies

The Xevo TQS system employs advanced triple quadrupole technology, comprising three key components:

1. Ion Source System:

• Standard UniSpray™ ion source providing 5-10x sensitivity improvement over conventional ESI
• Compatible with multiple ionization modes (ESI, APCI) for rapid switching
• Ion source temperature range: 100-600°C for diverse compound properties
• Innovative desolvation technology reduces matrix interference

2. Mass Analyzer:

• Q1 and Q3 mass range: 2-3,000 m/z
• Mass resolution: Unit mass resolution (0.7 FWHM)
• Q2 collision cell featuring T-Wave™ collision cell technology
• Adjustable collision energy: 0-120 eV (0.1 eV increments)

3. Detection System:

• High-energy dynode electron multiplier
• Dynamic range >10⁶ with linear correlation coefficient R²>0.99
• Acquisition speed up to 10,000 Da/sec
• Polarity switching time <20 ms

Performance Advantages and Innovative Features

The Xevo TQS system offers several groundbreaking technological advantages:

1. Ultra-High Sensitivity:

• MRM mode detection limits at fg level (on-column)
• Sonar™ technology enhances low-abundance component detection by 10x
• Patented StepWave™ ion optics system reduces background noise

2. Exceptional Stability:

• Mass axis stability <0.1 Da/24 hours
• Response stability RSD<5% (24-hour continuous testing)
• IntelliStart™ technology enables automatic tuning and calibration

3. Intelligent Operation:

• MassLynx™ software platform simplifies method development
• QuanOptimize™ supports automated method optimization
• Compliant with 21 CFR Part 11 regulations

4. High-Throughput Capabilities:

• Ultra-fast polarity switching
• Supports >1,000 MRM transitions
• Seamless integration with ACQUITY UPLC systems

Key Application Areas

With its precise quantitative capabilities, the Xevo TQS system excels in:

• Clinical Research: Newborn screening, vitamin detection, hormone analysis
• Pharmaceutical Development: Pharmacokinetic studies, bioequivalence evaluation, metabolite identification
• Food Safety: Pesticide residues, veterinary drug residues, mycotoxin detection
• Environmental Monitoring: Analysis of persistent organic pollutants in water and soil
• Forensic Toxicology: Drug abuse screening, quantitative toxicant analysis

For clinical 25-hydroxyvitamin D testing, the Xevo TQS system completes single-sample analysis in 2.5 minutes with intra-assay precision CV<5%. In pesticide multi-residue analysis, the system simultaneously monitors >300 pesticides, meeting EU SANTE/11813/2017 standards.

The Waters Xevo TQS triple quadrupole mass spectrometry system represents the forefront of quantitative mass spectrometry technology. Its innovative ion optics design and intelligent workflow provide laboratories with efficient, reliable solutions, making it the ideal tool for precise quantification of trace substances in complex matrices.