Device built-in

SCIEX 6500+ Triple Quadrupole Mass Spectrometer Introduction

Product Overview

The SCIEX 6500+ is a high-end triple quadrupole mass spectrometer that combines ultra-sensitive quantitative analysis with versatile scanning capabilities, designed for precise detection of trace compounds in complex matrices. Developed by SCIEX (USA) and now locally manufactured in China, this system is widely used in pharmaceutical development, environmental monitoring, food safety, and clinical research, excelling in quantitative analysis and structural identification of low-abundance targets.

Core Technical Features

1. Ultra-High Sensitivity & Stability

   • Equipped with IonDrive™ technology (including Turbo V ion source, QJet guide, and High Energy Detector+), delivering 100x higher sensitivity than previous models, capable of detecting pg-level (10^-12 g) compounds (e.g., 1 pg reserpine with S/N ≥1,000,000:1).
   • Linear dynamic range of 6 orders of magnitude, supporting >1,000 MRM transitions in a single run for simultaneous quantitation of trace to high-concentration analytes.

2. Multi-Functional Scanning Modes

   • Integrates triple quadrupole (MRM) and linear ion trap (LIT) capabilities, enabling MRM³, enhanced product ion (EPI) scans, and more—combining quantitation and qualitative analysis in one injection.
   • SelexION+ differential ion mobility technology enhances selectivity in complex matrices, reducing interference.

3. Intelligent Workflow

   • Compatible with MultiQuant and LipidView software for automated data processing and 21 CFR Part 11-compliant reporting.
   • Contamination-resistant design (e.g., VacShield technology) reduces maintenance time by 92%, ideal for high-throughput labs.

Typical Applications

• Clinical Diagnostics: Precise detection of metabolic biomarkers (e.g., bile acids, catecholamines) for disease subtyping and treatment evaluation.
• Environmental & Food Safety: Simultaneous analysis of 10 aristolochic acids or 115 pesticide residues with pg/mL-level sensitivity.
• Drug Development: Trace monitoring of genotoxic impurities (e.g., 4’-bromomethyl-2-cyanobiphenyl).

Industry Advantages

The 6500+ stands out for its "all-in-one" versatility, with localized production further reducing costs. Compared to conventional triple quadrupoles, its ion trap technology expands unknown compound screening capabilities, particularly excelling in macromolecule analysis (e.g., proteins, lipids).

Note: For optimal performance, pair with UHPLC systems (e.g., 1290 Infinity II) and operate in a temperature-controlled (23±2°C), low-humidity (<80%) environment.