Device built-in

Agilent LC/MS/MS 6470A-1290 Infinity II System Introduction

Product Overview

The Agilent 6470A Triple Quadrupole LC/MS System coupled with the 1290 Infinity II UHPLC is a high-performance solution designed for ultra-sensitive, high-throughput quantitative analysis. Combining the superior separation efficiency of UHPLC with the selective detection capabilities of triple quadrupole mass spectrometry, this system is widely used in pharmaceuticals, food safety, environmental monitoring, and clinical research, excelling in the precise quantification of trace compounds in complex matrices.

Core Technical Features

1. Ultra-High Sensitivity & Stability

   • The 6470A mass spectrometer features the Agilent Jet Stream (AJS) ion source, which enhances ionization efficiency via heated nitrogen sheath gas, delivering 5–10x higher sensitivity than conventional ESI and enabling detection at ppt levels.
   • The 1290 Infinity II LC system is equipped with a 1200 bar binary pump and 10 μL ultra-low dwell volume, leveraging Jet Weaver mixing technology for rapid gradient elution, reducing matrix effects, and improving LC/MS compatibility.

2. Intelligent Workflow

   • Supports dynamic MRM (dMRM) and triggered MRM (tMRM), intelligently allocating scan time to simultaneously analyze hundreds of compounds (e.g., 30 banned pesticides in traditional Chinese medicines) while balancing qualitative and quantitative needs.
   • MassHunter software includes 21 CFR Part 11 compliance tools, automating method transfer, data analysis, and report generation to streamline regulatory workflows.

3. Contamination Resistance & High Throughput

   • VacShield technology reduces maintenance time by 92% (to just 30 minutes), ensuring long-term instrument stability.
   • The 1290 Infinity II autosampler employs flow-through needle design and Dynamic Load & Clean (DLC), minimizing carryover to <0.001%, supporting 2,000 samples/day throughput.

Typical Applications

• Pharmaceuticals: Trace detection of genotoxic impurities (e.g., 4’-bromomethyl-2-cyanobiphenyl), compliant with ICH guidelines.
• Food Safety: High-efficiency screening of multi-class veterinary drug residues, reducing method development time by 50%.
• Environmental Monitoring: Accurate quantification of ppb-level organic pollutants in water.

Industry Advantages

The system’s "seamless method transfer" capability, powered by Intelligent System Emulation Technology (ISET), ensures data consistency across HPLC/UHPLC platforms from different vendors. Its modular design allows upgrades to 2D-LC or bio-compatible flow paths, catering to diverse research needs.

Note: For optimal performance, pair with ZORBAX RRHD 1.8 μm columns and operate in a temperature-controlled environment.