Device built-in

SCIEX QTRAP 4500MD Triple Quadrupole-Linear Ion Trap Mass Spectrometer Introduction

Product Overview

The SCIEX QTRAP 4500MD is a hybrid triple quadrupole-linear ion trap mass spectrometer that combines the high-precision quantitative capabilities of traditional triple quadrupoles with the versatile scanning modes of linear ion traps. Designed specifically for clinical diagnostics, bioanalysis, and complex matrix detection, this system utilizes QTRAP® technology to enable simultaneous quantitative and qualitative analysis, making it ideal for high-sensitivity detection of low-abundance targets while meeting the high-throughput and stability requirements of clinical laboratories.

Core Technical Features

1. Ultra-High Sensitivity & Precise Quantitation

   • Features Linear Accelerator™ ion trap technology, enhancing sensitivity by 100x in full-scan MS/MS mode, capable of detecting trace compounds at ppt (ng/L) levels.
   • AcQuRate™ pulse-counting detector ensures data reproducibility across a wide dynamic range (5 orders of magnitude), supporting >1000 MRM transitions in a single run.
   • Mass range: 5–2000 Da, mass accuracy <0.01% amu, suitable for precise quantitation in complex biological matrices.

2. Versatile Scanning & Contamination-Resistant Design

   • Supports MRM, MRM³, EPI, and neutral loss scanning, along with the linear ion trap’s full-scan and MS³ capabilities, enabling simultaneous quantitation and structural elucidation.
   • Curved LINAC® collision cell minimizes cross-contamination, while the QJet™ ion guide system enhances ion transmission efficiency for long-term, high-throughput operation.

3. Optimized for Clinical Diagnostics

   • CFDA-certified for quantifying endogenous compounds (e.g., vitamin D, hormones) and exogenous drugs (e.g., therapeutic monitoring compounds) in blood samples.
   • Equipped with Turbo V™ ion source, compatible with ESI/APCI and other ionization modes, with a flow rate range of 5 μL/min–3 mL/min for rapid LC separation.

Typical Applications

• Clinical Testing: Newborn genetic metabolic disorder screening, therapeutic drug monitoring (e.g., methamphetamine).
• Food Safety & Environmental Monitoring: Trace contaminant analysis (e.g., pesticide residues, PAHs).
• Metabolomics & Biomarker Research: Qualitative and quantitative analysis of low-abundance lipids and peptides.

Industry Advantages & Positioning

The QTRAP 4500MD stands out as a "multi-functional" workhorse for clinical and research laboratories, with its contamination-resistant design and automated workflows significantly improving detection efficiency. Compared to conventional triple quadrupole systems, its ion trap technology expands application boundaries, particularly excelling in unknown compound screening and structural elucidation.

Note: The system requires Analyst® software for data processing and is recommended for operation in temperature-controlled (±1°C) and low-humidity (<40%) environments.