Device built-in

Beckman DNA Sequencer GenomeLab GeXP Basic Introduction

Core Features and Technical Highlights

The GenomeLab GeXP Genetic Analysis System by Beckman Coulter is a versatile high-throughput platform integrating three major functions: gene expression quantification, DNA sequencing, and fragment analysis. Its key technological advantages include:

1. High-Throughput Multiplex Detection: Utilizing patented XP-PCR technology, it can simultaneously analyze 2-40 genes per well, with a maximum daily throughput of 7,680 gene detections, making it ideal for large-scale genetic research.
2. High Sensitivity and Precision: Linear polyacrylamide (LPA) gel electrophoresis enables accurate detection of gene expression changes as small as 0.5-fold (R²>0.99), requiring only 5-50ng of total RNA to initiate analysis.
3. Fully Automated Workflow: Features integrated online denaturation, automated sample loading, gel pouring, bubble removal, and optical calibration, supporting batch processing of 2×96-well plates (192 samples) with minimal manual intervention.

Innovative Design and Applications

• Multi-Task Compatibility: A single instrument can perform gene expression profiling, STR analysis, SNP genotyping, and DNA sequencing, suitable for tumor marker screening, stem cell research, GMO testing, and more.
• Intelligent Analysis Software: Includes a complete suite of tools from primer design to result interpretation, supporting complex genetic analyses such as MLPA and LOH.
• Flexible Scalability: The 4-wavelength laser-excited fluorescence detection system is compatible with multiple labeling dyes and seamlessly interfaces with downstream sequencing platforms.

Market Positioning and User Feedback

As a flagship product in Beckman Coulter's life sciences portfolio, the GenomeLab GeXP is renowned for its "all-in-one" versatility and "data reliability", particularly suited for comprehensive genetic analysis needs in small to medium-sized laboratories. Its modular design allows for upgrades to higher-throughput configurations (e.g., with SAGIAN Core systems) to meet industrial-scale applications like drug screening.

Conclusion: Through innovative LPA gel electrophoresis and XP-PCR technology, the GenomeLab GeXP significantly enhances detection efficiency while maintaining high precision, making it an optimal platform for genetic research and clinical diagnostics.