Device built-in

Agilent 6550 Q-TOF LC/MS System Introduction

System Overview

The Agilent 6550 Q-TOF is a high-resolution liquid chromatography-mass spectrometry (LC-MS) system that combines quadrupole mass filtering with time-of-flight (TOF) detection. Designed for high sensitivity and mass accuracy, it is widely used in metabolomics, proteomics, pharmaceutical research, environmental analysis, and food safety testing.

Key Technical Features

1. iFunnel Technology: Enhances ion transmission efficiency, achieving fg-level sensitivity (e.g., 1 pg reserpine, S/N >1000:1 in MS mode).
2. High Resolution & Mass Accuracy:
   • Resolution >42,000 FWHM (at m/z 2722)
   • Sub-ppm mass accuracy (<1 ppm with internal calibration).
3. Fast Data Acquisition: Up to 50 spectra/second, compatible with UHPLC separations and data-dependent MS/MS.
4. Wide Dynamic Range: >5 orders of magnitude in a single scan, enabling simultaneous detection of high- and low-abundance compounds.
5. Versatile Ion Sources: Supports ESI, APCI, and Dual Jet Stream ionization for diverse applications.

Applications

• Pharmaceuticals: Drug metabolism studies, impurity profiling, and ADMET research.
• Metabolomics/Proteomics: High-confidence identification of metabolites and proteins.
• Environmental/Food Safety: Screening for pesticides, toxins, and pollutants.
• Forensics: Toxicological analysis and DNA adduct detection.

Operational Advantages

• MassHunter Software: Streamlines data processing, quantification, and database matching.
• Robust Performance: Combines high sensitivity, speed, and mass precision in a single platform.

The 6550 Q-TOF is a benchmark system for complex sample analysis, offering unmatched reliability for both qualitative and quantitative workflows.