Device built-in

Agilent 6560 Ion Mobility Q-TOF Mass Spectrometry System Introduction

System Overview

The Agilent 6560 Ion Mobility Q-TOF is a high-resolution ion mobility-quadrupole-time-of-flight tandem mass spectrometry system developed by Agilent Technologies, which perfectly integrates ion mobility separation technology with high-resolution mass spectrometry. Featuring innovative drift tube ion mobility separation technology, this FDA 21 CFR Part 11 certified system adds a new dimension of collision cross section (CCS) to traditional m/z separation, significantly enhancing complex sample analysis capabilities. It has become the benchmark platform in proteomics, metabolomics, and biopharmaceutical research.

Core Technical Features

1. Ion Mobility Separation System:

   • High-precision drift tube design with resolution >100 (Ω/ΔΩ), supporting positive/negative ion mode switching
   • CCS measurement accuracy <2% with reproducibility RSD<0.3%
   • Mobility separation range 50-2500m²/Vs, maximum separation voltage 200V/cm
   • Orthogonal configuration with TOF mass analyzer for multidimensional separation

2. Q-TOF Mass Spectrometry System:

   • Mass range 20-40,000m/z with resolution >40,000 FWHM
   • Mass accuracy <1ppm (internal standard), scanning speed up to 50 spectra/s
   • Sensitivity reaching 1fg on-column reserpine (S/N>200:1)
   • Equipped with Dual Jet Stream ion source, improving ion transmission efficiency by 80%

System Advantages

1. Revolutionary Separation Capability:

   • Ion mobility dimension increases peak capacity by 10-100 times
   • Effectively separates isomeric and conformational isomers
   • Significantly reduces matrix interference and improves low-abundance compound detection

2. Outstanding Application Performance:

   • Proteomics: Intact protein analysis and conformational change studies
   • Metabolomics: Isomer differentiation and lipid double-bond localization
   • Biopharmaceuticals: Antibody-drug conjugate (ADC) characterization
   • Environmental Analysis: Persistent pollutant screening

3. Intelligent Operation:

   • MassHunter software enables one-click CCS database matching
   • Supports IM-MS and HDMSE data acquisition modes
   • Complies with GLP standards with complete audit trail functionality

By introducing the new dimension of ion mobility, the Agilent 6560 system provides a groundbreaking solution for complex sample analysis. Currently deployed in over 500 top research institutions worldwide, it is driving omics research into the 4D era.