Device built-in

Thermo Scientific LCQ Fleet/UltiMate 3000 LC-MS System Introduction

System Overview

The Thermo Scientific LCQ Fleet/UltiMate 3000 is a cost-effective liquid chromatography-mass spectrometry system developed by Thermo Fisher Scientific, integrating the UltiMate 3000 high-performance liquid chromatograph with the LCQ Fleet ion trap mass spectrometer. Utilizing innovative ion trap technology, this FDA and CE-certified system provides an economical solution for small molecule drug development, food safety testing, and environmental pollutant analysis, making it particularly suitable for routine LC-MS analysis in small-to-medium sized laboratories.

Core Component Technical Features

1. UltiMate 3000 Liquid Chromatograph:

   • Binary high-pressure gradient system with maximum pressure of 620bar, compatible with sub-2μm particle columns
   • Flow rate range 0.001-5mL/min, injection precision ±0.5%, ideal for trace sample analysis
   • Equipped with intelligent column oven (5-80°C) and dual-wavelength UV detector with baseline noise <±0.25×10⁻⁵AU
   • Dual-piston design reduces pulsation, achieving retention time reproducibility RSD<0.2%

2. LCQ Fleet Ion Trap Mass Spectrometer:

   • Mass range 50-2000amu with scan speed up to 15,000amu/s, full scan sensitivity reaching 500fg reserpine (S/N>50:1)
   • Patented ion focusing technology improves ion transmission efficiency by 30%, with detection limits down to ppb level
   • Supports MSⁿ multistage mass spectrometry (n=10), maximum collision energy 100eV
   • Standard dual ion sources (ESI and APCI) with switching time <5 minutes

Combined System Advantages

1. Analytical Performance:

   • Simultaneous high-sensitivity quantification and structural elucidation of compounds in complex matrices
   • MSⁿ provides rich fragmentation information, especially suitable for unknown compound identification
   • Rapid positive/negative ion mode switching meets high-throughput screening needs

2. Application Fields:

   • Pharmaceutical R&D: Drug metabolite identification, impurity analysis and drug interaction studies
   • Food Safety: Pesticide/veterinary drug residues, illegal additives and toxin detection
   • Environmental Monitoring: Emerging contaminant screening in water and soil
   • Clinical Research: Small molecule biomarker validation

3. Cost-Effectiveness:

   • 50% lower acquisition and maintenance costs compared to high-end mass spectrometers
   • User-friendly operation with only 15 minutes daily maintenance
   • Modular design supports future upgrades

This integrated system combines the high-efficiency separation of UltiMate 3000 with the multistage MS capabilities of LCQ Fleet, delivering professional-level LC-MS analysis for small-to-medium laboratories as an entry-level LC-MS solution with exceptional cost-performance ratio.