Device built-in

AB Sciex Triple Quad MSD QTRAP 3200 Mass Spectrometry System Introduction

Product Overview

The AB Sciex Triple Quad MSD QTRAP 3200 is a high-performance hybrid triple quadrupole linear ion trap mass spectrometry system developed by SCIEX, which perfectly combines the precise quantitative capabilities of a triple quadrupole with the multi-stage scanning functionality of a linear ion trap. Featuring innovative QTRAP® technology, this FDA and CE-IVD certified system enables simultaneous quantitative and qualitative detection in a single analysis, providing comprehensive solutions for pharmaceutical R&D, food safety, and environmental monitoring. It has become the "gold standard" platform for clinical research and routine testing.

Core Technical Features

1. Hybrid Ion Trap Technology: The patented QTRAP® design allows seamless switching between MRM quantitative scanning and ion trap full scan modes via simple software commands. The linear ion trap achieves scanning speeds up to 20,000 Da/s with 10-fold greater sensitivity than conventional triple quads.

2. Enhanced Ion Source: Turbo V™ ion source supports dual ESI/APCI ionization modes with temperatures up to 700°C. Combined with QJet® ion guide technology, ion transmission efficiency improves by 50%, enabling detection of compounds at fg levels.

3. Differential Ion Mobility: Optional SelexION® component separates isomeric compounds through ion mobility, improving resolution by 5-10 times, especially suitable for complex matrix sample analysis.

Performance Parameters

• Mass range: 5-1,250 Da (extendable to 3,000 Da)
• Scanning speed: 12,000 Da/s (QqQ mode), 20,000 Da/s (ion trap mode)
• Sensitivity: >500,000:1 S/N for 1pg reserpine on-column injection in MRM mode
• Dynamic range: >10⁶ for accurate quantification from trace to high concentration levels
• Mass stability: <0.1 amu/24 hours

Application Fields

The QTRAP 3200 excels in multiple domains:

1. Drug Metabolism Studies: Simultaneous quantification of parent drugs and qualification of metabolites using MRM-IDA-EPI scanning mode
2. Clinical Testing: Newborn screening, vitamin D testing, and hormone analysis compliant with CLIA certification requirements
3. Food Safety: Multi-residue screening of pesticides and veterinary drugs with MRM³ technology eliminating matrix interference
4. Environmental Monitoring: Trace detection of persistent organic pollutants (POPs) and emerging contaminants

System Advantages

1. Dual Functionality: Combines triple quadrupole quantification with ion trap qualification in one instrument
2. Ultra-high Sensitivity: Pulse counting detector provides 10-fold greater sensitivity than traditional electron multipliers
3. Intelligent Method Development: Built-in Method Wizard software automatically optimizes MRM ion pairs and collision energy
4. Regulatory Compliance: Meets 21 CFR Part 11 requirements with complete audit trail functionality

With its exceptional performance and reliability, the AB Sciex QTRAP 3200 has been adopted by over 3,000 laboratories worldwide, providing dependable technical support for qualitative and quantitative analysis of complex samples.