Device built-in

SCIEX Triple Quad 5500 LC-MS/MS System Introduction

System Overview

The SCIEX Triple Quad 5500 is a high-performance triple quadrupole liquid chromatography-tandem mass spectrometry (LC-MS/MS) system developed by AB SCIEX (now SCIEX), integrating ultra-high sensitivity with exceptional stability. Featuring innovative QTRAP® Ready technology, this CE IVD-certified system simultaneously delivers the precise quantitative capabilities of a triple quadrupole and the qualitative functions of a linear ion trap. It has become the "gold standard" analytical platform in pharmaceutical R&D, clinical research, and food safety applications.

Core Technical Features

The system is equipped with a third-generation QJet 2 ion guide and eQ™ electronics enabling 50ms rapid positive/negative ion switching. With a mass range of 5-1,250 Da, it achieves MRM sensitivity of >500,000:1 S/N for 1pg reserpine. The innovative SelexION® differential ion mobility technology separates isomeric compounds, while the Turbo V™ ion source supports dual ESI/APCI modes. Featuring a dynamic range of 10⁶ and AcQuRate pulse counting detector, it ensures accuracy in trace-level analysis.

System Advantages

1. Dual functionality: Activates QTRAP capabilities combining triple quadrupole quantification with ion trap qualification
2. Ultra-high sensitivity: 10x more sensitive than comparable instruments, with MRM³ mode eliminating matrix interference
3. Rapid analysis: Scanning speed of 12,000 Da/s, detecting up to 2,500 MRM ion pairs per analysis
4. Intelligent data acquisition: Supports 7 scan modes including MRM-IDA-EPI and enhanced full scan

Typical Application Fields

• Pharmaceutical R&D: Pharmacokinetic studies, metabolite identification and impurity analysis
• Clinical research: Biomarker validation and targeted proteomics
• Food safety: Screening of pesticide/veterinary drug residues and illegal additives
• Environmental monitoring: Analysis of persistent organic pollutants (POPs)

Service Support

SCIEX provides comprehensive method development support and operator training. The system complies with international standards including EPA Method 8270. Its exceptional stability (<5% CV across 1,300 consecutive injections) and modular design adapt to evolving laboratory needs.