Device built-in

Introduction to Waters LC/MS/MS Xevo TQ-S Micro/H-Class High-Performance Chromatography System

The Waters Xevo TQ-S Micro/H-Class is a compact yet high-performance LC/MS/MS system specifically optimized for highly sensitive quantitative analysis, widely applied in pharmaceuticals, clinical diagnostics, food safety, and environmental monitoring.

Key Features

1. Outstanding Performance

   • Equipped with T-Wave collision cell technology, supporting high-speed MRM (500 transitions/second) and RADAR full scan mode for simultaneous qualitative and quantitative data acquisition, with scanning speeds up to 20,000 Da/s and polarity switching in just 20 ms.
   • Exceptional sensitivity: >10,000:1 S/N for 1 pg reserpine in ESI mode, >200:1 S/N for 100 pg 17α-hydroxyprogesterone in APCI mode.

2. Flexible Compatibility

   • Standard ZSpray dual orthogonal ion source compatible with multiple ionization modes including ESI, APCI, ESCi, and UniSpray, with optional APGC and APPI extensions.
   • Seamless integration with ACQUITY UPLC H-Class/I-Class systems enables high-precision separation of narrow peaks (2-3 seconds).

3. Intelligent Operation & Stability

   • IntelliStart technology enables automatic calibration and optimization, while StepWave off-axis ion focusing technology reduces matrix interference (<0.1 Da mass drift over 24 hours).
   • Xtended Dynamic Range (XDR) detector expands dynamic range to 6 orders of magnitude for trace-to-high concentration analysis.

Technical Advantages

• Compact Design: 42% smaller footprint and 34% lower power consumption than conventional instruments, ideal for space-constrained labs.
• High Throughput: Supports up to 16,384 MRM transitions per injection for large-scale screening.
• Robustness: <9% RSD in peak area after 1,000 continuous injections over 5 days.

Applications

• Pharmaceuticals: Drug metabolite quantification and impurity identification.
• Clinical Testing: Newborn genetic disease screening (e.g., Hcy metabolic pathway analysis).
• Food Safety: Pesticide residue detection (e.g., glyphosate in cucumbers), compliant with global MRL standards.

With its modular design and waters_connect/MassLynx software support, the Xevo TQ-S Micro/H-Class represents the gold standard in high-efficiency LC/MS/MS analysis.