Device built-in

Introduction to Waters LC/MS/MS Xevo TQ-MS

The Waters Xevo TQ-MS is a high-performance triple quadrupole liquid chromatography-mass spectrometry system specifically designed for highly sensitive and selective LC/MS/MS quantitative analysis. It is widely applied in pharmaceuticals, clinical diagnostics, food safety, and environmental monitoring.

Key Features

1. Exceptional Sensitivity and Stability

   • Equipped with T-Wave™ collision cell technology, supporting high-speed MRM (Multiple Reaction Monitoring) and RADAR™ full scan mode for simultaneous acquisition of quantitative and qualitative data, enhancing analytical efficiency.
   • Mass range: 2–2048 m/z, with a scan speed of up to 10,000 Da/s and polarity switching in just 20 ms, ideal for complex matrix analysis.

2. Versatile Ionization Techniques

   • Features a standard ZSpray™ dual orthogonal ion source, compatible with ESI, APCI, ESCi, and optional APPI, APGC for diverse compound analysis.

3. Intelligent Workflow

   • IntelliStart™ technology enables automatic calibration and system optimization, simplifying method development.
   • Quanpedia™ database automatically generates MRM methods, supporting high-throughput screening (up to 16,384 MRM transitions per analysis).

Technical Advantages

• Sensitivity:
  • ESI mode: >10,000:1 S/N for 1 pg reserpine.
  • APCI mode: >200:1 S/N for 100 pg 17α-hydroxyprogesterone.
• Reproducibility: <0.1 Da mass drift over 24 hours, ensuring data reliability.
• Compatibility: Seamless integration with ACQUITY UPLC systems, supporting high-precision quantification of narrow peaks (2–3 seconds).

Applications

• Pharmaceuticals: Drug metabolite quantification, impurity identification.
• Clinical Testing: Newborn genetic disease screening, therapeutic drug monitoring.
• Food Safety: Pesticide residue analysis (e.g., paraquat).

With its modular design and MassLynx™ software integration, the Xevo TQ-MS stands as a benchmark instrument for high-efficiency LC/MS/MS analysis in modern laboratories.