Device built-in

Introduction to Waters LC/MS/MS Xevo TQD

The Waters Xevo TQD is a high-performance benchtop tandem quadrupole mass spectrometer designed for advanced LC/MS/MS applications, widely used in pharmaceuticals, clinical diagnostics, food safety, and environmental monitoring.

Key Features

1. High-Performance Separation

   • Equipped with T-Wave™ collision cell technology, supporting high-speed MRM (Multiple Reaction Monitoring) and RADAR™ acquisition mode for simultaneous quantitative and qualitative data acquisition.
   • Mass range: 2–2048 m/z, with a scan speed of up to 10,000 Da/s and polarity switching in just 20 ms, ideal for complex sample analysis.

2. Versatile Ionization Techniques

   • Features a ZSpray™ dual orthogonal API source, supporting ESI, APCI, ESCi, and optional APPI, APGC, ASAP for broad compound coverage.

3. Automation & Intelligence

   • IntelliStart™ technology enables automatic system optimization and status monitoring, simplifying method development.
   • Quanpedia database and Auto-Dwell function facilitate automated MRM method generation and optimized data acquisition.

Technical Advantages

• Sensitivity:
  • ESI mode: >10,000:1 S/N for 1 pg reserpine.
  • APCI mode: >200:1 S/N for 100 pg 17α-hydroxyprogesterone.
• Stability: <0.1 Da mass drift over 24 hours, ensuring excellent reproducibility.
• High Throughput: Supports 16,384 MRM transitions per run, ideal for large-scale screening.

Applications

• Clinical Testing: Newborn genetic metabolic disorder screening, therapeutic drug monitoring (TDM).
• Food Safety: Pesticide residue analysis (e.g., diquat, paraquat).
• Pharmaceutical R&D: High-sensitivity quantification of drug metabolites.

With its modular design and MassLynx™ software integration, the Xevo TQD is a benchmark instrument for high-efficiency LC/MS/MS analysis in modern laboratories.

This version maintains technical accuracy while optimizing clarity and readability for an English-speaking audience. Let me know if you'd like any refinements!