Device built-in

PALL Ultrafiltration Clamp (0.5-2.5m²) Product Introduction

The PALL Ultrafiltration Clamp is a core component specifically designed for tangential flow filtration (TFF) systems, compatible with membrane cassettes ranging from 0.5-2.5m² in area. Widely used in biopharmaceuticals, vaccine production, and recombinant protein purification, its modular design and high compatibility support seamless scale-up from laboratory-scale development to industrial production.

Key Features

1. Multi-Specification Membrane Compatibility

   • Supports PALL Omega series membrane cassettes (PES material) with molecular weight cut-offs (MWCO) from 1-1000kDa, meeting diverse process requirements (e.g., antibody concentration, virus purification).
   • Accommodates single or multiple cassettes (e.g., 2.5m² cassettes require thick gaskets) and ensures stable sealing through clamp locking.

2. High-Precision Sealing Design

   • Utilizes specialized plastic gaskets (e.g., P/N: PSSP2XC10), which require periodic replacement to maintain sealing integrity.
   • Recommended torque wrench tightening (45-50Nm for 0.5-2.5m² cassettes) prevents leaks or membrane damage.

3. Flexible System Integration

   • Compatible with PALL Centramate, Minimate, and other TFF systems, enabling parallel cassette connections for higher throughput (e.g., 5×0.5m² cassettes for 2.5m² total area).
   • Works with stainless steel flow distribution plates (e.g., SXLSC02) to optimize flow paths and minimize pressure drop.

4. GMP Compliance

   • Constructed from 316L stainless steel with surface roughness Ra≤0.8μm, meeting pharmaceutical-grade cleanliness standards.
   • Supports integrity testing (diffusion flow method) to ensure process reliability.

Typical Applications

• Biopharmaceuticals: Concentration and buffer exchange for monoclonal antibodies and vaccines.
• Gene Therapy: AAV vector purification and endotoxin removal.
• Continuous Processing: Integration with PALL Allegro bioreactors for end-to-end production.

Key Advantages

The PALL Ultrafiltration Clamp simplifies operations through standardized design, combining high-capacity membranes (processing up to 150L/m² per cycle) with low protein adsorption properties to significantly enhance process efficiency. Its modular structure allows rapid cassette changes, reducing cross-contamination risks and making it an ideal choice for bioprocess development.

For specific models (e.g., UFC10CC system) or purchasing inquiries, contact authorized PALL distributors (e.g., Beijing Zeping).

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