Device built-in

PALL 5-Layer Depth Filtration Clamp Product Introduction

The PALL 5-Layer Depth Filtration Clamp is a high-performance filtration system specifically designed for biopharmaceuticals, vaccine production, and cell culture clarification. Featuring a multi-layer composite structure and modular design, it efficiently removes cell debris, colloidal impurities, and endotoxins, meeting scalable needs from laboratory to industrial production.

Core Structure & Technical Features

1. Five-Layer Filtration Media

   • Layered Design: Composed of a cellulose matrix, diatomaceous earth filter aid, and positively charged resin, forming a three-dimensional mesh structure that progressively captures particles (0.1-20μm).
   • Charge Adsorption: The resin layer electrostatically adsorbs negatively charged host cell proteins (HCP) and DNA, enhancing filtrate purity.

2. Supradisc II Patented Membrane Stack

   • Vertically stacked capsule-style membranes (0.25-2.0m²) are secured by the clamp, eliminating the need for traditional stainless steel housings and reducing cleaning validation costs.
   • Compatible with the PALL Stax System, supporting 50-20,000L processing volumes and multiple flow directions (top-to-bottom or bottom-to-top).

3. High Capacity & Stability

   • Single-pass filtration capacity reaches 150-174L/m² (tested data), with turbidity below 7 NTU and product loss rate <10%.
   • Pharmaceutical-grade Seitz filter material ensures low extractables and endotoxins (<0.06 EU/mL), complying with FDA standards.

4. Modular & User-Friendly Operation

   • Flow distribution plates accommodate various membrane packs (e.g., SXLSC02, SXPSC05P), enabling quick installation and replacement.
   • A secure locking mechanism minimizes backpressure rupture risks, allowing single-operator handling.

Typical Applications

• Biopharmaceuticals: Clarification of cell culture fluids (e.g., CHO cells, E. coli lysates) for monoclonal antibodies and vaccines.
• Blood Products: Primary filtration of plasma proteins and serum.
• Continuous Processing: Integration with PALL Allegro Bioreactors for end-to-end production.

Key Advantages

The PALL 5-Layer Depth Filtration Clamp combines multi-stage interception + charge adsorption to enhance efficiency. Its single-use design significantly reduces cross-contamination risks, making it an optimal solution for high-capacity, high-stability bioprocessing.

For detailed specifications or purchasing inquiries, contact authorized PALL distributors (e.g., Beijing Zeping).

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