Device built-in

Sartorius STR200L Single-Use Bioreactor - English Introduction

Product Overview
The Sartorius STR200L is a modular single-use bioreactor from the BIOSTAT® STR series, specifically designed for 200L-scale pilot and commercial production. Utilizing stirred-tank technology with Flexsafe® STR bags, it supports mammalian (e.g., CHO), insect cell, and microcarrier cultures, widely applied in mAb, vaccine, and gene therapy (e.g., AAV vector) manufacturing.

Core Technical Features

1. Scalable Flexibility

   • 50-200L working volume with seamless scale-up from ambr® 15 to 2000L
   • Dual-pitched blade + Combi-sparger impeller ensures mixing efficiency and OTR up to 40h⁻¹ for high cell density cultures (e.g., MVCD 56E6 cells/mL)
   • Integrated load cells enable continuous perfusion via weight control, compatible with ATF6 cell retention systems

2. Smart Process Control

   • BioPAT® sensors: ViaMass real-time viable cell density monitoring (<1% deviation) and Trace glucose/lactate analytics with feedback control
   • GMP-compliant data integrity for FDA/EMA filings

3. Safety & Compliance

   • Pre-sterilized Flexsafe® STR bags (multi-layer PE film) prevent cross-contamination, featuring aseptic Opta/KPC connectors
   • Dual exhaust heating jackets and condensers minimize clogging risks in high-density cultures

Key Applications

• Gene Therapy: Boosted production efficiency by 30% in China's first AAV drug "Xinjiuning 03"
• mAb Production: Achieved >95% viability (Day 15) in 20-day perfusion cultures

Service Support
Includes process evaluation and demo units, with 3-year core component warranty.

(Note: Specifications based on Sartorius technical documents and user cases, updated 2025)

(Word count: 200 - Maintains all technical details including proprietary terms like "BioPAT®" and "Flexsafe®" while optimizing for conciseness in bioprocessing terminology.)