Since April 2025, trade tariffs between China and the United States have continued to escalate. Against the backdrop of tariff hikes, imports of high-end scientific instruments have been restricted, leading to a significant increase in procurement costs and lead times. At the same time, a large number of old and obsolete equipment in laboratories need to be updated, resulting in an urgent demand for domestically produced equipment with excellent performance, safety, and controllability. Under such circumstances, CoreTech, relying on its strong R&D capabilities and innovation, has launched the ultra-high performance liquid chromatography system Leo series and high performance liquid chromatography system Sco series. These products have injected new impetus into the rise of domestic liquid chromatography systems and provided high-quality domestic alternatives for various industries, research institutions, and universities. Breaking the Import Monopoly The liquid chromatography track is the largest single-product market in the analytical instrument industry. Due to its large market capacity, it has attracted many players. By 2024, there were over 200 domestic liquid chromatography manufacturers, but the product homogeneity rate was as high as 65%. Among the numerous participants, the four major imported brands—Waters, Agilent, Shimadzu, and Thermo Fisher—are powerful and occupy more than 90% of the domestic market share. Meanwhile, in recent years, the growth rate of China's biopharmaceutical market has slowed down, the overall economic environment is sluggish, and competition among imported brands has become increasingly fierce. To compete for market share, imported brands have successively lowered their product prices. Under such circumstances, the living space of domestic liquid chromatography brands has been further compressed, facing severe challenges. However, Chengdu CoreTech has become a leader in multiple segmented tracks of domestic liquid chromatography brands in just a few years. The company has been committed to breaking the technical monopoly of imported products and has invested a lot of energy in technological research and development. In the new Leo and Sco series liquid chromatography products, CoreTech has made significant breakthroughs. 99% of the core components of the whole machine have been successfully localized. This achievement is of great significance, avoiding the "bottleneck" dilemma in product production and supply caused by tariff policies and other issues. The localization of core components not only ensures the stability and independent controllability of the supply chain but also provides greater space and flexibility for product performance optimization and upgrading. Ultra-Fast Analysis Earlier this year, the company officially released the third-generation ultra-high performance liquid chromatograph. Its unique appearance is like a miniaturized "three-door refrigerator". In terms of performance, the product has demonstrated excellent analysis efficiency, with the sample analysis time shortened by nearly 10 times compared to the second-generation product. Wang Yu, the company's operation director, introduced that the 2024 new product has two significant highlights compared to the previous generation. One of them is that the product's pressure can reach 20,000 PSI. Taking the Mariana Trench, the deepest part of the Pacific Ocean, which is about 11,000 meters deep, as an example, the system pressure of this product is about 20% higher than the pressure at the deepest part of the Mariana Trench. Such high system pressure puts extremely high requirements on the product's design materials and manufacturing processes. Currently, only CoreTech in China has mastered this technology. CoreTech has made a major breakthrough in the field of ultra-high performance liquid chromatography. It is the first domestic enterprise to independently develop all core components of UPLC (Ultra-High Performance Liquid Chromatography). This achievement has broken foreign technological blockades, filled the domestic gap in this technology, and laid a solid foundation for the development of domestic ultra-high performance liquid chromatographs. Another prominent advantage of the ultra-high performance liquid chromatograph version 3.0 is that it can significantly shorten the sample analysis time, thereby remarkably improving the analysis efficiency of researchers. Wang Yu gave an example: when analyzing vitamins in blood samples, the analysis work that used to take 20 minutes can now be completed in just over 2 minutes. Opening a New Chapter of Development The mass spectrometry R&D field is a relatively niche circle, where many mass spectrometry R&D clients know each other. Chengdu CoreTech has accurately positioned itself in the mass spectrometry-matched UHPLC track and won high recognition from clients with high-quality products and services. Through word-of-mouth among clients, more and more domestic mass spectrometry companies have taken the initiative to seek cooperation with Chengdu CoreTech for front-end ultra-high performance liquid chromatography products. The recognition of CoreTech's ultra-high performance liquid chromatography by mass spectrometry clients has generated a good radiating effect. In the customs system procurement at the end of 2024, CoreTech stood out and became the only winning domestic ultra-high performance liquid chromatography product. This achievement not only affirms the quality of CoreTech's products but also establishes a good brand image for it in the market. The domestic substitution of scientific instruments is an arduous task, and domestic scientific instrument brands face many challenges in the early stage of development. How to gain a firm foothold in an industry with numerous giants and fierce competition, and take a distinctive development path, is a question that every brand needs to think deeply about. CoreTech's success provides valuable experience for domestic scientific instrument brands. It tells us that on the road of domestic substitution, focusing on segmented tracks, adhering to technological innovation, and providing high-quality services are effective ways for domestic scientific instrument brands to achieve breakthroughs. With the continuous advancement of technology and the gradual expansion of the market, it is believed that CoreTech will achieve greater success in the future and make greater contributions to the development of domestic scientific instruments.