Device built-in

Introduction to Sartorius Molecular Interaction Analysis System

The Sartorius Molecular Interaction Analysis System is an advanced analytical platform based on Bio-Layer Interferometry (BLI) and Surface Plasmon Resonance (SPR) technologies, designed for real-time, label-free detection of biomolecular interaction kinetics, binding affinity, and concentration quantification. This system is widely applied in antibody drug development, vaccine research, small molecule screening, and fundamental scientific research.

Core Technical Features

1. Label-Free Detection Technology

   • BLI Technology: Monitors phase shifts in interferometric light caused by molecular binding on biosensor surfaces, enabling real-time analysis of association/dissociation processes without sample labeling or complex pretreatment.
   • SPR Technology (Octet SF3 model): Detects molecular interactions through surface plasmon resonance signal changes, supporting high-sensitivity small molecule analysis (detection limit: 150 Da).

2. High-Throughput Flexible Configuration

   • Offers 2-channel (R2), 4-channel (R4), 8-channel (R8), and ultra-high-throughput HTX (196-channel) models compatible with 96/384-well plate automation.
   • Supports on-site throughput upgrades (e.g., R4 to R8) to meet needs from research to GMP production.

3. Intelligent Operation & Data Analysis

   • Integrated temperature control (15-40°C) and agitation (0-1500 RPM) for temperature-sensitive samples.
   • 21 CFR Part 11-compliant software provides real-time kinetic parameters (kₐ, k_d, K_D) and audit trail functionality.

Key Applications

• Drug Development: Antibody-antigen affinity screening, fragment compound optimization.
• Basic Research: Protein-nucleic acid interactions, virus-host binding mechanisms.
• Industrial Testing: Direct analysis of crude samples (e.g., cell supernatants) to accelerate process development.

Advantages & Industry Recognition

• Efficiency: Completes 96-sample analysis in <5 minutes (10× faster than conventional methods).
• Reliability: Cited in >10,000 global publications, including 300+ Cell/Nature/Science papers.
• Compliance: BLI technology is recognized by USP 1108 as a standard method.

Sartorius' dual-technology platform (BLI + SPR) delivers end-to-end solutions for life sciences, spanning target discovery to quality control release.