Device built-in

Thermo Scientific TSQ Endura Triple Quadrupole LC/MS System Introduction

The Thermo Scientific TSQ Endura is a high-performance triple quadrupole liquid chromatography-mass spectrometry system specifically designed for high-sensitivity quantitative analysis. Featuring innovative ion optics design and intelligent operation interface, this system demonstrates exceptional performance in drug metabolism, environmental monitoring, food safety, and forensic toxicology applications.

Core Technical Features

The TSQ Endura's technological innovations are primarily reflected in three key modules:

1. Intelligent Ion Source System:

• Equipped with Easy Max NG ion cartridge, integrating HESI and APCI sources in a unified design - simply replace the spray needle to switch ionization modes
• Angled spray design with asymmetric cut surface below the ion transfer channel rapidly removes excess solvent spray, significantly extending maintenance intervals
• Constant nitrogen flow at the exhaust port effectively eliminates solvent vapor and reduces baseline noise

2. High-Efficiency Ion Transfer System:

• RF Lens Design: Stainless steel integrated lens assembly provides superior ion transmission efficiency and focusing capability, while being easy to disassemble and clean
• Curved Ion Transfer Path: Combined with neutral particle deflector design, effectively filters neutral particle interference and maintains clean ion optics
• Hyperbolic Quadrupoles: Patented asymmetric RF voltage technology significantly improves ion transmission efficiency compared to conventional designs

3. Active Collision Cell Design:

• Curved collision cell structure with axial DC field enables segmented ion acceleration, generating more abundant secondary fragments
• Higher pressure argon as collision gas increases fragment ion yield and detection sensitivity

Performance Advantages

The TSQ Endura excels in several critical performance metrics:

1. Ultra-High Sensitivity:

• ESI positive ion mode: S/N ratio ≥3000:1 for 50fg reserpine (m/z 609>195)
• Dynamic range exceeding 10⁶, enabling accurate detection of ppb-level trace components

2. Exceptional Stability:

• Mass axis stability ≤0.05 amu/24 hours ensures long-term quantitative accuracy
• Neutral particle deflector maintains performance stability after thousands of injections

3. User-Friendly Operation:

• Automatic ion source recognition with automatic gas/electrical connections during installation
• Drag-and-drop method editor and TraceFinder software platform simplify method development

Key Applications

The TSQ Endura demonstrates professional analytical capabilities across multiple fields:

1. Pharmaceutical Research: High-sensitivity quantitative analysis of drug metabolites, compliant with 21CFR Part 11 requirements
2. Food Safety: Rapid screening of pesticide residues, veterinary drug residues and other contaminants
3. Environmental Monitoring: Accurate detection of environmental pollutants like nonionic surfactants in surface water
4. Forensic Toxicology: Reliable identification of opioids and their metabolites in urine
5. Protein Analysis: Absolute quantitative analysis of target proteins

Technical Specifications Summary

Through its innovative hardware design and intelligent software platform, the TSQ Endura elevates laboratory productivity and quantitative analysis reliability to new heights, providing an ideal solution for trace substance analysis in complex matrices. Its outstanding durability and ease of use make it particularly suitable for long-term stable operation in high-throughput laboratories.