Device built-in

Waters TQS 2011 Triple Quadrupole Mass Spectrometer with Acquity M-Class UPLC System

The Waters TQS 2011 triple quadrupole mass spectrometer coupled with the Acquity M-Class ultra-performance liquid chromatography system represents a high-performance LC-MS platform specifically designed for trace sample analysis. Through innovative ion optics design and microflow LC technology, this integrated system delivers ultra-high sensitivity and excellent reproducibility for proteomics, metabolomics, and other trace sample research applications, establishing itself as a vital analytical tool in life science research since 2011.

System Configuration and Core Technologies

This integrated system consists of two key modules:

1. Acquity M-Class Ultra-Performance Liquid Chromatography System:

• Optimized for trace sample analysis with flow rate range of 1-200 μL/min
• Features M-Class column technology with 0.1-0.3mm internal diameter
• System delay volume <2μL, significantly improving separation efficiency for trace samples
• Innovative low-dispersion flow path design maintains sharp peak shapes

2. TQS 2011 Triple Quadrupole Mass Spectrometer:

• Mass range: 2-3,000 m/z with 0.7 FWHM resolution
• Incorporates StepWave ion optics technology providing 10x sensitivity improvement over conventional designs
• T-Wave collision cell technology with adjustable collision energy (0-120 eV)
• Polarity switching time <20 ms to meet rapid analysis requirements

Performance Advantages

The TQS 2011 with Acquity M-Class system offers several groundbreaking technological advantages:

1. Trace Sample Analysis Capability:

• Minimum sample requirement reduced to nanoliter level
• Maintains excellent peak shape even at 1μL/min flow rate
• Ideal for precious biological sample analysis

2. Ultra-High Sensitivity:

• MRM mode detection limits at fg level (on-column)
• Signal-to-noise enhancement technology significantly improves low-abundance component detection
• Delivers stable response even at 100 pg/mL concentration

3. Exceptional Stability:

• Mass axis stability <0.1 Da/24 hours
• Response stability RSD <5% (24-hour continuous testing)
• Innovative vacuum system design reduces maintenance requirements

Key Applications

With its outstanding trace sample analysis performance, this system excels in:

• Proteomics: Identification and quantification of low-abundance proteins
• Metabolomics: Analysis of metabolites in trace biological samples
• Neuroscience Research: Neurotransmitter detection in cerebrospinal fluid and other trace samples
• Drug Metabolism Studies: Analysis of drugs and their metabolites in trace blood samples
• Translational Medicine: Analysis of precious clinical biopsy samples

In proteomics research, the system can identify hundreds of proteins from nanoliter samples. For metabolomics applications, it can detect over 200 metabolites from just 1μL of serum.

The Waters TQS 2011 with Acquity M-Class system represented the forefront of trace sample LC-MS analysis technology in 2011. The perfect integration of innovative microflow separation technology with high-sensitivity detection capabilities provided life science research with a powerful analytical tool.