Device built-in

Introduction to Shimadzu LCMS-8050/Nexera HPLC System

The Shimadzu LCMS-8050 triple quadrupole liquid chromatography-tandem mass spectrometry (LC-MS/MS) system coupled with Nexera ultra-high performance liquid chromatography (UHPLC) forms a cutting-edge analytical platform for pharmaceutical research, food safety testing, and environmental monitoring. Renowned for its ultra-high sensitivity (detection limits at femtogram level) and ultra-fast analysis (scan speed up to 30,000 u/sec), this integrated system delivers intelligent operation and serves as an ideal solution for trace analysis in complex matrices.

Core Technological Highlights

1. Nexera UHPLC System

   • Withstands pressures up to 130 MPa and is compatible with sub-2 μm columns, enabling ultra-fast separations (analysis cycles as short as 1 minute).
   • Modular design includes binary/quaternary gradient pumps, a low-carryover autosampler (SIL-40C), and an intelligent temperature control system to minimize cross-contamination.

2. Triple Quadrupole Mass Spectrometer (LCMS-8050)

   • Features a heated ESI ion source (desolvation temperature: 650°C) and UFsweeper III collision cell technology, significantly enhancing ionization efficiency with sensitivity reaching attogram levels.
   • Ultra-fast polarity switching (5 ms) and multiple reaction monitoring (MRM) (555 channels/sec) support simultaneous detection of positive/negative ions in a single run, ideal for high-throughput screening (e.g., 12 drugs or 29 pesticide residues).

3. Intelligence & Durability

   • LabSolutions software integrates LC/MS control with AI-assisted method optimization and real-time diagnostics for simplified workflows.
   • Fully inert flow path design reduces matrix interference, processing over 400 samples daily with easy maintenance (ion source replacement in just 30 minutes).

Key Applications

• Pharmaceuticals: Quantification of picomolar-level peptides (e.g., semaglutide) in biological samples.
• Environmental Monitoring: Detection of pesticide residues and persistent organic pollutants (POPs) in water.
• Food Safety: High-throughput screening of pesticide residues, veterinary drugs, and illegal additives.

By balancing speed, sensitivity, and stability, this system meets the stringent demands of both research and industrial quality control.